Department of Neurology, The Second People's Hospital of Deyang City, No. 340 Minjiang West Road, Deyang, Sichuan, China.
Department of Neurology, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou, Sichuan, China.
Biomed Res Int. 2020 Dec 30;2020:6685740. doi: 10.1155/2020/6685740. eCollection 2020.
To investigate the relationship between mean platelet volume (MPV) level and carotid atherosclerosis and prognosis in patients with acute cerebral infarction. A retrospectively included 160 patients with acute cerebral infarction classified by TOAST classification as aortic atherosclerosis as the observation group. To analyze the relationship between MPV and carotid atherosclerosis, and use receiver operating characteristic (ROC) curves to analyze the role of MPV in predicting the prognosis of acute cerebral infarction in the observation group, grouping patients with different MPV by cut-off value, and analyze the differences in factors between the two groups of patients.
MPV has a positive correlation with carotid atherosclerosis in patients with acute cerebral infarction. Multivariate logistic regression analysis revealed that increased MPV was an independent predictor of poor functional outcome in patients with acute cerebral infarction (Odds Ratio (OR): 6.152, 95% CI: 2.385-13.625, < 0.01). ROC curve analysis showed that the area under the curve for MPV to predict poor prognosis was 0.868 (95% CI: 0.787-949, < 0.01). The cutoff value, sensitivity, and specificity were 12.65, 76.2%, and 87.6%. Compared with patients with MPV < 12.65 at admission, patients with higher MPV levels (MPV ≥ 12.65) at admission have larger infarct size, more severe carotid artery stenosis, poor short-term prognosis, and higher mortality.
MPV level is closely related to the degree of carotid atherosclerosis in patients with acute cerebral infarction, and it is also an independent predictor of poor prognosis in patients with acute cerebral infarction at 3 months.
探讨平均血小板体积（MPV）水平与急性脑梗死患者颈动脉粥样硬化及预后的关系。方法：回顾性纳入 160 例急性脑梗死患者，根据 TOAST 分类分为主动脉粥样硬化组为观察组。分析 MPV 与颈动脉粥样硬化的关系，采用受试者工作特征（ROC）曲线分析观察组 MPV 对急性脑梗死预后的预测作用，以截断值分组患者不同的 MPV，分析两组患者间各因素的差异。
急性脑梗死患者 MPV 与颈动脉粥样硬化呈正相关。多因素 logistic 回归分析显示，MPV 升高是急性脑梗死患者不良功能结局的独立预测因素（优势比（OR）：6.152，95%置信区间（CI）：2.385-13.625， < 0.01）。ROC 曲线分析显示，MPV 预测不良预后的曲线下面积为 0.868（95%CI：0.787-949， < 0.01）。截断值、敏感度和特异度分别为 12.65、76.2%和 87.6%。与入院时 MPV<12.65 的患者相比，入院时 MPV 水平较高（MPV≥12.65）的患者梗死灶较大、颈动脉狭窄更严重、短期预后较差、死亡率更高。
MPV 水平与急性脑梗死患者颈动脉粥样硬化程度密切相关，也是急性脑梗死患者 3 个月预后不良的独立预测因子。
