载脂蛋白 E 多态性与中国 2 型糖尿病缺血性脑卒中患者风险的关联。
Association of Apolipoprotein E Polymorphisms and Risks of Ischemic Stroke in Chinese Patients with Type 2 Diabetes Mellitus.
机构信息
Department of Transfusion Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
Clinical Laboratory, China-Japan Friendship Hospital, Beijing 100029, China.
出版信息
J Diabetes Res. 2021 Jan 3;2021:8816996. doi: 10.1155/2021/8816996. eCollection 2021.
BACKGROUND
The apolipoprotein E () gene polymorphisms have been intensively studied in patients with type 2 diabetes mellitus (T2DM) and ischemic stroke (IS) in recent years. However, it is unclear whether gene polymorphisms are correlated with increased risk for developing IS in T2DM patients. Thus, this study was designed to examine the association between gene polymorphisms and risks of IS in Chinese patients with T2DM.
METHODS
This case-control study enrolled 243 subjects with T2DM as controls, and 210 subjects with T2DM complicated with IS as case patients. The genotypes were determined using real-time PCR while HbA1c and lipid levels were detected using commercially available kits.
RESULTS
The systolic blood pressure (SBP), diastolic blood pressure (DBP), and the proportion of patients with a history of hypertension were higher in the case patients than that in the controls. We confirmed that the 2/3 genotype, as well as SBP and history of hypertension, was the independent risk factor for developing IS in T2DM patients.
CONCLUSIONS
We conclude that the 2/3 genotype might contribute to the increased risk for developing IS in Chinese patients with T2DM.
背景
近年来，载脂蛋白 E（）基因多态性在 2 型糖尿病（T2DM）和缺血性脑卒中（IS）患者中得到了深入研究。然而，目前尚不清楚 是否基因多态性与 T2DM 患者发生 IS 的风险增加相关。因此，本研究旨在探讨 基因多态性与中国 T2DM 患者发生 IS 的风险之间的关系。
方法
本病例对照研究纳入 243 例 T2DM 患者作为对照组，210 例 T2DM 合并 IS 患者作为病例组。采用实时 PCR 法检测基因型，采用商业试剂盒检测糖化血红蛋白（HbA1c）和血脂水平。
结果
与对照组相比，病例组的收缩压（SBP）、舒张压（DBP）和高血压病史患者比例更高。我们证实，2/3 基因型以及 SBP 和高血压病史是 T2DM 患者发生 IS 的独立危险因素。
结论
我们得出结论，2/3 基因型可能导致中国 T2DM 患者发生 IS 的风险增加。
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