Department of Endocrinology, 220742The First Hospital of Hebei Medical University, Shijiazhuang, China.
Hebei International Joint Research Center for Brain Science, Shijiazhuang, China.
Clin Appl Thromb Hemost. 2022 Jan-Dec;28:10760296221092405. doi: 10.1177/10760296221092405.
To investigate the correlation between ApoE gene polymorphism and the risk of lower extremity arterial disease (LEAD) in T2DM patients of Han nationality in northern China. One hundred and fifty patients with T2DM and 150 patients with T2DM combined with LEAD were enrolled in the study and assigned to the control group and the case group, respectively. The results revealed that the number of epsilon 2 (ε2) genotype carriers in the case group was significantly lower than that in the control group (case vs control: 8.0% vs 15.4%), and the distribution of the ε2 allele frequency was similar to that of the genotype (case vs control: 4.0% vs 8.4%). A binary logistic regression analysis revealed that age, waist-to-hip ratio (WHR), and gender were risk factors for T2DM with LEAD and that the ApoE ε2 carriers was a protective factor (odds ratio [OR] 0.380; 95% confidence interval [CI] 0.162-0.892; = .026). In male subjects, ε2 carriers were more common in the control group (case vs control:7.8% vs 24.1%), while epsilon 4 (ε4) carriers were more common in the case group (case vs control: 23.3% vs 8.6%); the distribution of frequency of ε2 and ε4 alleles was more common in the control group and the case group, respectively (case vs control: 3.9% vs 12.1%, 12.8% vs 5.2%). In male, age and WHR were risk factors for the disease, and being an ε2 carrier was a protective factor. Being an ApoE gene ε2 carrier is a protective factor for LEAD in male patients with T2DM that are of Han nationality in northern China.
探讨载脂蛋白 E（ApoE）基因多态性与中国北方汉族 2 型糖尿病（T2DM）患者下肢动脉疾病（LEAD）风险的相关性。
选取 150 例 T2DM 患者和 150 例 T2DM 合并 LEAD 患者为研究对象，分别纳入对照组和病例组。结果：病例组 ε2 基因型携带者数量明显低于对照组（病例组 vs 对照组：8.0% vs 15.4%），ε2 等位基因频率的分布与基因型相似（病例组 vs 对照组：4.0% vs 8.4%）。二元逻辑回归分析显示，年龄、腰臀比（WHR）和性别是 T2DM 合并 LEAD 的危险因素，ApoE ε2 携带者是保护因素（比值比[OR] 0.380；95%置信区间[CI] 0.162-0.892；P=0.026）。在男性中，ε2 携带者在对照组中更为常见（病例组 vs 对照组：7.8% vs 24.1%），而 ε4 携带者在病例组中更为常见（病例组 vs 对照组：23.3% vs 8.6%）；ε2 和 ε4 等位基因的频率分布在对照组和病例组中更为常见（病例组 vs 对照组：3.9% vs 12.1%，12.8% vs 5.2%）。在男性中，年龄和 WHR 是疾病的危险因素，而 ε2 携带者是保护因素。
在中国北方汉族 T2DM 男性患者中，ApoE 基因 ε2 携带者是 LEAD 的保护因素。
