Alsada Sherifa A, Ba-Essa Ebtesam M, Alsaffar Alya A
Department of Family Medicine, Safwa General Hospital, Ministry of Health, Safwa, Eastern Province, Saudi Arabia.
Department of Endocrinology, Diabetes and Endocrine Center, Dammam Medical Complex, Ministry of Health, Dammam, Eastern province, Saudi Arabia.
Adv Med. 2020 Dec 22;2020:1247294. doi: 10.1155/2020/1247294. eCollection 2020.
Saudi Arabia is reported to have the highest number of children and adolescents with T1DM. However, data concerning glycemic control during adolescence are lacking.
To determine glycemic control at transition stage from pediatric to adult clinics, determine HBA1c patterns during follow-up, and identify any clinical or demographic variables that may predict a distinctive glycemic pattern.
Observational retrospective study. . Dammam Medical Complex, secondary care hospital. . Adolescents aged ≥12 years, with HbA1c recorded at least once a year over 4 years of follow-up, were eligible for inclusion. A trajectory analysis from 2008 to 2019 was conducted, using latent class growth modelling (LCGM), and two-sample -tests and Fisher's exact tests were conducted to determine whether there was a statistically significant difference in demographic and clinical variables. . 44 patients.
61.36% were referred from pediatric clinics, and 84% were on multiple insulin daily injections. For the trajectory prediction, two groups were identified. Group 1 comprised 71.7%, had high HbA1c values at age 13 (HbA1c, 11.28%), and had a significant and stable decrease in HbA1c values with age (-0.32, < 0.00). Group 2 comprised 28.2%, showed poor HbA1c values at age 13 (HbA1c, 13.28%), and showed increase in HbA1c values slightly by age 15, which then steadily decreased with age (-0.27). Results indicated that the initial HBA1c value was a significant predictor for group trajectory (=0.01), while the remaining variables did not have any significance.
Our study identified two groups with poorly controlled diabetes; however, the first group performed relatively better than the second group. Both groups almost doubled their targets, with a trend towards HbA1c reduction by the age of 19 in both groups. . Retrospective study with convenient, small sample size.
据报道，沙特阿拉伯患有1型糖尿病的儿童和青少年数量最多。然而，缺乏有关青少年血糖控制的数据。
确定从儿科诊所过渡到成人诊所阶段的血糖控制情况，确定随访期间糖化血红蛋白（HbA1c）的变化模式，并识别任何可能预测独特血糖模式的临床或人口统计学变量。
观察性回顾性研究。达曼医疗中心，二级护理医院。年龄≥12岁、在4年随访期间每年至少记录一次HbA1c的青少年符合纳入标准。使用潜在类别增长模型（LCGM）对2008年至2019年进行轨迹分析，并进行双样本t检验和费舍尔精确检验，以确定人口统计学和临床变量是否存在统计学上的显著差异。44名患者。
61.36%的患者从儿科诊所转诊而来，84%的患者每天多次注射胰岛素。对于轨迹预测，识别出两组。第1组占71.7%，13岁时HbA1c值较高（HbA1c，11.28%），且HbA1c值随年龄显著且稳定下降（-0.32，P<0.00）。第2组占28.2%，13岁时HbA1c值较差（HbA1c，13.28%），15岁时HbA1c值略有上升，然后随年龄稳步下降（-0.27）。结果表明，初始HbA1c值是组轨迹的显著预测因素（P=0.01），而其余变量无任何显著性。
我们的研究识别出两组糖尿病控制不佳的患者；然而，第一组的表现相对优于第二组。两组几乎都使目标值翻倍，两组在19岁时均有HbA1c降低的趋势。回顾性研究，样本方便但规模小。
