Huh J, Baines L, Talbot D, MacFie C
Northern Deanery Newcastle upon Tyne UK.
Department of Nephrology Freeman Hospital Newcastle upon Tyne UK.
Anaesth Rep. 2021 Jan 13;9(1):16-19. doi: 10.1002/anr3.12092. eCollection 2021 Jan-Jun.
Cytokine release syndrome is a systemic inflammatory response that can be triggered by a variety of factors such as infection or exposure to certain drugs, particularly novel T cell-engaging immunotherapies. Severe cytokine release syndrome as a complication following treatment with anti-thymocyte globulin, although recognised, is not well-reported in the literature. We report the case of a 64-year-old man who developed catastrophic cytokine release syndrome after receiving anti-thymocyte globulin during kidney transplantation. We highlight the importance of prompt recognition of severe cytokine release syndrome with strategies to aid survival in life-threatening cases.
细胞因子释放综合征是一种全身性炎症反应，可由多种因素触发，如感染或接触某些药物，特别是新型T细胞接合免疫疗法。严重的细胞因子释放综合征作为抗胸腺细胞球蛋白治疗后的并发症，虽然已被认识到，但在文献中报道较少。我们报告了一例64岁男性在肾移植期间接受抗胸腺细胞球蛋白治疗后发生灾难性细胞因子释放综合征的病例。我们强调了及时识别严重细胞因子释放综合征的重要性，并提出了在危及生命的病例中帮助患者生存的策略。
