Private Practice, Izmir, Turkey.
Department of Orthodontics, Faculty of Dentistry, Ege University, Izmir, Turkey.
Prog Orthod. 2021 Jan 25;22(1):4. doi: 10.1186/s40510-020-00345-1.
One of the most unfavorable side effects of fixed orthodontic treatment is white spot lesions (WSLs). Although the most important approach is prevention of WSLs, it is also essential to evaluate the efficacy of the remineralization agents. However, there is no concurrence in the literature with respect to the remineralization process of these agents. The objective of the present study was to evaluate the effects of different fluoride varnishes, enamel matrix protein, and self-assembling peptide derivatives with varying chemical compositions on remineralization of artificially created WSLs in vitro using quantitative light-induced fluorescence (QLF).
Artificial WSLs were created on bovine enamel samples using acidic buffer solution (pH 5, 10 days). Specimens were randomly allocated to six groups (n = 10/group): (1) Emdogain (Straumann, Basel, Switzerland), (2) Curodont Repair (Credentis AG, Switzerland), (3) Duraphat (Colgate-Palmolive, New York, NY), (4) Clinpro XT (3 M ESPE, Pymble, New South Wales, Australia), (5) Enamel Pro Varnish (Premier Dental Products, PA, USA), and (6) control (untreated). The agents were applied to the WSLs according to the manufacturers' instructions. Fluorescence loss (ΔF), lesion area (area), and impact (ΔQ) values of enamel surfaces were quantified by QLF-D Biluminator (Inspektor-Pro, Amsterdam, The Netherlands) at baseline and after 7, 14, and 21 days of application of the respective materials.
ΔF value presented a significantly decreasing trend throughout the 21 days for all groups except the Duraphat and Enamel Pro varnishes. The changes between 14th and 21st days of the Clinpro XT varnish application were significantly higher than Emdogain, Curodont, and Enamel Pro. The Curodont group showed higher lesion area changes between the first and second week in comparison to the Emdogain, Clinpro XT, and Enamel Pro groups, whereas Clinpro XT assured the highest reduction from the second to the third week of the observation period.
The fluorescence loss was significantly reduced with enamel matrix protein, self-assembling peptide, and light-curable fluoride varnishes in the analysis for 21 days. Curodont and Clinpro XT were effective in diminishing the fluorescence loss and lesion area compared to the Duraphat, Enamel Pro fluoride varnishes, and Emdogain in different time points.
固定正畸治疗最不利的副作用之一是白垩斑（WSL）。虽然预防 WSL 是最重要的方法，但评估再矿化剂的疗效也是必不可少的。然而，文献中对于这些药物的再矿化过程没有一致的看法。本研究的目的是使用定量光荧光（QLF）评估不同氟化物漆、釉基质蛋白和具有不同化学成分的自组装肽衍生物对人工 WSL 再矿化的影响。
使用酸性缓冲液（pH 5，10 天）在牛牙釉质样本上人工创建 WSL。将标本随机分为六组（每组 n = 10）：（1）Emdogain（施特劳曼，巴塞尔，瑞士），（2）Curodont 修复（瑞士 Credentis AG），（3）Duraphat（高露洁棕榄，纽约，NY），（4）Clinpro XT（3M ESPE，皮姆布勒，新南威尔士，澳大利亚），（5）Enamel Pro Varnish（Premier Dental Products，PA，美国）和（6）对照组（未处理）。根据制造商的说明，将试剂应用于 WSL。使用 QLF-D Biluminator（Inspektor-Pro，阿姆斯特丹，荷兰）在基线和应用相应材料后的 7、14 和 21 天分别量化牙釉质表面的荧光损失（ΔF）、病变面积（area）和影响（ΔQ）值。
除了 Duraphat 和 Enamel Pro 清漆外，所有组的ΔF 值在 21 天内均呈显著下降趋势。Clinpro XT 清漆应用的第 14 天和第 21 天之间的变化明显高于 Emdogain、Curodont 和 Enamel Pro。与 Emdogain、Clinpro XT 和 Enamel Pro 组相比，Curodont 组在第一周到第二周之间的病变面积变化更大，而 Clinpro XT 组在观察期的第二周到第三周内确保了最高的减少量。
在 21 天的分析中，釉基质蛋白、自组装肽和光固化氟化物清漆显著降低了荧光损失。与 Duraphat、Enamel Pro 氟化物清漆和 Emdogain 相比，Curodont 和 Clinpro XT 在不同时间点更有效地减少荧光损失和病变面积。
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