Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Ain Shams University, Organization of African Unity St.-Abbasia, Cairo, 11566, Egypt.
BMC Oral Health. 2023 Feb 17;23(1):110. doi: 10.1186/s12903-023-02799-1.
This study aimed to compare the effect of Clinpro™ White varnish containing 5% sodium fluoride (NaF) and functionalized tricalcium phosphate, MI varnish containing 5% NaF and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), and 38% Silver diamine fluoride (SDF) in preventing demineralization of treated white spot lesions (WSLs) in enamel of primary teeth.
Forty-eight primary molars with artificial WSLs were allocated into four groups as follows: Group 1: Clinpro white varnish, Group 2: MI varnish, Group 3: SDF, and Group 4: control (no treatment). The three surface treatments were applied for 24 h and then enamel specimens were subjected to pH cycling. Thereafter, the mineral content of specimens was evaluated by Energy Dispersive X-ray Spectrometer and the lesion depth was assessed via Polarized Light Microscope. One-way ANOVA followed by Tukey's post hoc test were used at p ≤ 0.05 to identify significant differences.
Insignificant difference in mineral content was observed among treatment groups. Treatment groups exhibited significantly higher mineral content compared to control except for Fluoride (F). MI varnish showed the highest mean calcium (Ca) ion content (66.57 ± 0.63), and Ca/P (2.19 ± 0.11), followed by Clinpro white varnish, and SDF. MI varnish also displayed the highest phosphate (P) ion content (31.46 ± 0.56), followed by SDF (30.93 ± 1.02), and Clinpro white varnish (30.53 ± 2.19). Fluoride content was highest in SDF (0.93 ± 1.18), followed by MI (0.89 ± 0.34) and Clinpro (0.66 ± 0.68) varnishes. Significant difference in lesion depth was observed among all groups (p < 0.001). The lowest mean lesion depth (µm) was found in MI varnish (226.23 ± 44.25) which was significantly lower than Clinpro white varnish (285.43 ± 44.70), SDF (293.32 ± 46.82), and control (576.69 ± 42.66). Insignificant difference in lesion depth was found between SDF and Clinpro varnish.
In primary teeth, WSLs treated with MI varnish displayed better resistance to demineralization compared to WSLs treated with Clinpro white varnish and SDF.
本研究旨在比较 Clinpro™ White 含 5%氟化钠 (NaF) 和功能性磷酸三钙的釉质漆、MI 含 5% NaF 和酪蛋白磷酸肽-无定形磷酸钙 (CPP-ACP) 的釉质漆以及 38% 氟化银 (SDF) 在预防乳牙釉质表面白斑 (WSL) 脱矿方面的效果。
将 48 颗人工 WSL 的乳磨牙分为四组：第 1 组：Clinpro 白色釉质漆，第 2 组：MI 釉质漆，第 3 组：SDF，第 4 组：对照组（无处理）。三组表面处理剂均作用 24 小时，然后进行 pH 循环。之后，通过能量色散 X 射线光谱仪评估标本的矿物质含量，通过偏光显微镜评估病变深度。采用单因素方差分析（ANOVA）和 Tukey 事后检验（post hoc test），p 值≤0.05 为差异有统计学意义。
各组治疗之间的矿物质含量无显著差异。治疗组的矿物质含量明显高于对照组，除了氟化物（F）。MI 釉质漆显示出最高的平均钙 (Ca) 离子含量（66.57 ± 0.63）和 Ca/P（2.19 ± 0.11），其次是 Clinpro 白色釉质漆和 SDF。MI 釉质漆还显示出最高的磷酸盐 (P) 离子含量（31.46 ± 0.56），其次是 SDF（30.93 ± 1.02）和 Clinpro 白色釉质漆（30.53 ± 2.19）。氟化物含量最高的是 SDF（0.93 ± 1.18），其次是 MI（0.89 ± 0.34）和 Clinpro（0.66 ± 0.68）釉质漆。所有组之间的病变深度均有显著差异（p < 0.001）。MI 釉质漆的平均病变深度（µm）最低（226.23 ± 44.25），明显低于 Clinpro 白色釉质漆（285.43 ± 44.70）、SDF（293.32 ± 46.82）和对照组（576.69 ± 42.66）。SDF 和 Clinpro 釉质漆之间的病变深度无显著差异。
在乳牙中，与 Clinpro 白色釉质漆和 SDF 处理的 WSL 相比，MI 釉质漆处理的 WSL 显示出更好的抗脱矿能力。
