Khugaeva V K
Biull Eksp Biol Med. 1988 Mar;105(3):300-2.
Dalargin (a synthetic analog of leu-enkephalin), when applied to the microvessel surface or administered intramuscularly at doses 0.004-40.0 micrograms/kg increased the permeability of the rat mesenteric microvascular wall and activated the lymph flow due to enhanced contraction of lymphatic microvascular wall and valves. Moreover, Dalargin evoked leukocyte migration from venules and activated the intestinal muscular contractions.
达乐argin(亮氨酸脑啡肽的合成类似物),当以0.004 - 40.0微克/千克的剂量应用于微血管表面或肌肉注射时,会增加大鼠肠系膜微血管壁的通透性,并由于淋巴管微血管壁和瓣膜收缩增强而激活淋巴流动。此外,达乐argin会引起白细胞从小静脉迁移,并激活肠道肌肉收缩。