Kohl A, Werner A, Buntrock P, Diezel W, Adrian K, Titov M I
Dermatol Monatsschr. 1989;175(9):561-72.
The wound-healing agent Dalargin, a hexapeptide and varios of its cleavage products were tested in a wound-healing model on the basis of granulation in rat. Three days after wounding (p.op.) an increase in granulation was observed at Dalargin concentrations of 10 micrograms/ml and 50 micrograms/ml. Seven days p.op. an increase was observed already at a Dalargin concentration of 5 micrograms/ml. The cleavage products of Dalargin had no stimulating effect on granulation. A histologic differentiation of the different cell parts in the granulation tissue led to an increased total number of cells. The concentration of 5 micrograms/ml induced both an increase in the number of endothelial cells and fibroblasts, the concentration of 50 micrograms/ml induced just an increase of the number of endothelial cells. The possible bases of the mode of operation are being discussed. The stimulating effect on wound healing as described could be confirmed by the results obtained in our animal experiments.
伤口愈合剂达拉argin（一种六肽）及其多种裂解产物在大鼠肉芽形成的伤口愈合模型中进行了测试。受伤后3天（经口给药），在达拉argin浓度为10微克/毫升和50微克/毫升时观察到肉芽形成增加。受伤后7天，在达拉argin浓度为5微克/毫升时就已观察到增加。达拉argin的裂解产物对肉芽形成没有刺激作用。肉芽组织中不同细胞部分的组织学分化导致细胞总数增加。5微克/毫升的浓度诱导内皮细胞和成纤维细胞数量增加，50微克/毫升的浓度仅诱导内皮细胞数量增加。正在讨论其作用方式的可能基础。我们动物实验获得的结果证实了上述对伤口愈合的刺激作用。
