Kopyl'tsov V N, Zhordanna K I, Solov'ev Iu N, Revazova E S
Biull Eksp Biol Med. 1988 Mar;105(3):324-6.
Pregnancy in nude mice proved to be a favourable period for a successful human cervical tumor transplantation. This approach made it possible to obtain human cervical tumors, serially transplanted to nude mice. After several passages the tumor acquired the ability to be transplanted to nonpregnant female mice. The tumor retained a histological pattern of an original human tumor.
事实证明,裸鼠怀孕期是成功进行人宫颈肿瘤移植的有利时期。这种方法使得获得人宫颈肿瘤成为可能,并将其连续移植到裸鼠体内。经过几次传代后,肿瘤获得了移植到未怀孕雌性小鼠体内的能力。该肿瘤保留了原始人肿瘤的组织学特征。