Stupina A S, Berezhkov N V
Biull Eksp Biol Med. 1988 Mar;105(3):380-2.
Light and electron microscopy and morphometry revealed an age-related increase in the average size of hepatocytes and their nuclei in 24- and 30-month-old rats compared to 8-month-old animals, the density of hepatocytes distribution per area unit being decreased. In 24-month-old rats the number of binuclear hepatocytes increased with a subsequent decrease in their number in 30-month-old animals, which accounted for the shift in regeneration processes during ageing to predominantly intracellular one. The number of sinusoidal cells per area unit in three age groups was statistically similar. The results of morphometry and electron microscopy suggest that the compensatory-adaptive processes during hepatocyte ageing were mediated by intracellular regeneration, which led to cellular and nuclear hypertrophy similar to that observed in cells of static population (neurons, cardiomyocytes).
光镜、电镜及形态计量学研究显示，与8月龄大鼠相比，24月龄和30月龄大鼠的肝细胞及其细胞核平均大小随年龄增长而增大，单位面积内肝细胞的分布密度降低。24月龄大鼠双核肝细胞数量增加，而在30月龄动物中其数量随后减少，这解释了衰老过程中再生过程向主要为细胞内再生的转变。三个年龄组单位面积内的窦状隙细胞数量在统计学上相似。形态计量学和电镜结果表明，肝细胞衰老过程中的代偿性适应过程是由细胞内再生介导的，这导致了细胞和细胞核肥大，类似于在静态细胞群（神经元、心肌细胞）中观察到的情况。
