Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, USA.
Department of Dermatology, George Washington University School of Medicine, 2150 Pennsylvania Avenue, Suite 2B-425, , Washington D.C., 20037, USA.
Arch Dermatol Res. 2022 Aug;314(6):609-611. doi: 10.1007/s00403-021-02188-0. Epub 2021 Jan 25.
Population-based risk-factors for the rising prevalence of childhood atopic dermatitis (AD) in the United States are not well elucidated. We hypothesized that trends of birthweight over the past 2 decades contributed to the increasing prevalence of childhood AD in the United States. We sought to determine whether trends of birthweight were associated with trends of childhood AD prevalence over time in the US. Data were analyzed from the 1997-2018 National Health Interview Survey (N = 238,767 children). The prevalence [95% confidence interval] of childhood AD increased from 1997 (7.9% [7.4-8.5%]) to 2018 (12.6% [11.6-13.5%]). Whereas, mean [95% confidence interval] birthweight decreased from 1997 (3.35 kg [3.34-3.37 kg]) to 2018 (3.30 kg [3.28-3.31 kg]). A 1 kg increase in birthweight was associated with a slightly increased odds of AD (adjusted odds ratio [95% confidence interval] 1.039 [1.009-1.070]). However, there were no significant interactions between low or high birthweight and year as predictors of childhood AD prevalence overall or in any age group. In conclusion, there is a slight association between greater birthweights and AD prevalence. However, temporal trends of birthweight do not account for trends of childhood AD prevalence in the United States.
人群中导致美国儿童特应性皮炎（AD）患病率上升的风险因素尚不清楚。我们假设过去 20 年来的出生体重趋势导致了美国儿童 AD 患病率的增加。我们试图确定出生体重趋势是否与美国儿童 AD 患病率的时间趋势有关。本研究的数据来自 1997 年至 2018 年的全国健康访谈调查（N=238767 名儿童）。儿童 AD 的患病率（95%置信区间）从 1997 年（7.9%[7.4-8.5%]）增加到 2018 年（12.6%[11.6-13.5%]）。而平均（95%置信区间）出生体重从 1997 年（3.35 公斤[3.34-3.37 公斤]）下降到 2018 年（3.30 公斤[3.28-3.31 公斤]）。出生体重增加 1 公斤，AD 的患病几率略有增加（调整后的比值比[95%置信区间]1.039[1.009-1.070]）。然而，低出生体重或高出生体重与年份作为预测儿童 AD 总体患病率或任何年龄组患病率的指标之间没有显著的相互作用。总之，出生体重越大与 AD 患病率之间存在轻微的关联。然而，出生体重的时间趋势并不能解释美国儿童 AD 患病率的变化趋势。
