强力霉素在犬体内的药代动力学
Pharmacokinetics of doxycycline in dogs.
作者信息
Wilson R C, Kemp D T, Kitzman J V, Goetsch D D
机构信息
Department of Physiology, College of Veterinary Medicine, Auburn University, Alabama 36849.
出版信息
Can J Vet Res. 1988 Jan;52(1):12-4.
Abstract
Six adult dogs were given doxycycline hyclate at a dosage of 5 mg/kg of body weight intravenously so that pharmacokinetic parameters could be evaluated. Serum doxycycline concentrations were determined over a 48 h period using a modified agar well bioassay. Compartmental pharmacokinetic evaluation of the serum concentration time data indicated that doxycycline has a half-life of 10.36 h, a body clearance of 1.68 +/- 0.44 mL/min/kg, and a volume of distribution at steady state of 1.468 +/- 0.237 L/kg. Doxycycline pharmacokinetics are favorable for therapeutic use in the dog.
摘要
给6只成年犬静脉注射5mg/kg体重的盐酸多西环素，以便评估其药代动力学参数。使用改良的琼脂孔生物测定法在48小时内测定血清多西环素浓度。血清浓度-时间数据的房室药代动力学评估表明，多西环素的半衰期为10.36小时，机体清除率为1.68±0.44mL/（min·kg），稳态分布容积为1.468±0.237L/kg。多西环素的药代动力学特性有利于在犬类中进行治疗应用。
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