代谢介质决定抗核抗体亚型与系统性硬化症特定临床症状的关联。

Metabolic mediators determine the association of antinuclear antibody subtypes with specific clinical symptoms in systemic sclerosis.

机构信息

Department of Dermatology, Medical University of Warsaw, Poland.

出版信息

Adv Med Sci. 2021 Mar;66(1):119-127. doi: 10.1016/j.advms.2020.12.007. Epub 2021 Jan 22.

DOI:10.1016/j.advms.2020.12.007

PMID:33494024

Abstract

PURPOSE

The aim of this study was to investigate the possible link between different types of systemic sclerosis-specific antinuclear antibodies, adipokines and endothelial molecules which were recently found to have a pathogenic significance in systemic sclerosis.

MATERIALS/METHODS: Serum concentration of adiponectin, resistin, leptin, endothelin-1, fractalkine and galectin-3 were determined in the sera of patients with systemic sclerosis (n = 100) and healthy controls (n = 20) using ELISA.

RESULTS

The following associations between antinuclear antibodies and increased serum concentrations were identified: anticentromere antibodies with endothelin-1 (p < 0.0001; mean level in patients 2.21 vs control group 1.31 pg/ml), anti-topoisomerase I antibodies with fractalkine (p < 0.0001; 3.68 vs 1.68 ng/ml) and galectin-3 (p = 0.0010, 6.39 vs 3.26 ng/ml). Anti-RNA polymerase III antibodies were associated with increased resistin (p < 0.0001; 15.13 vs 8.54 ng/ml) and decreased adiponectin (p < 0.0001; 2894 vs 8847 ng/ml).

CONCLUSION

In systemic sclerosis metabolic and vascular factors may serve as mediators between immunological abnormalities and non-immune driven clinical symptoms.

摘要

目的

本研究旨在探讨不同类型的系统性硬化症特异性抗核抗体与脂肪因子和内皮分子之间可能存在的联系，这些脂肪因子和内皮分子最近被发现与系统性硬化症的发病机制有关。

材料/方法：采用 ELISA 法检测 100 例系统性硬化症患者（病例组）和 20 例健康对照者（对照组）血清中脂联素、抵抗素、瘦素、内皮素-1、 fractalkine 和半乳糖凝集素-3 的浓度。

结果

发现抗核抗体与血清浓度升高之间存在以下关联：抗着丝粒抗体与内皮素-1（p<0.0001；患者组平均水平为 2.21 pg/ml，对照组为 1.31 pg/ml），抗拓扑异构酶 I 抗体与 fractalkine（p<0.0001；3.68 vs 1.68 ng/ml）和半乳糖凝集素-3（p=0.0010，6.39 vs 3.26 ng/ml）。抗 RNA 聚合酶 III 抗体与抵抗素升高（p<0.0001；15.13 vs 8.54 ng/ml）和脂联素降低（p<0.0001；2894 vs 8847 ng/ml）有关。