猪局灶性对称性脊髓软化症：口服包封亚硒酸钠的实验性复制

Wilson T M, Hammerstedt R H, Palmer I S, deLahunta A

Department of Veterinary Science, Pennsylvania State University, University Park 16802.

Can J Vet Res. 1988 Jan;52(1):83-8.

Sodium selenite (encapsulated as doses of 1.4 mg, 2.6 mg and 4.2 mg per kilogram of body weight) was given orally on a daily basis to male weaner pigs, and features of these animals were compared to a control group. Porcine focal symmetrical poliomyelomalacia was produced in all experimental groups between 3 and 20 days after initiation of the treatment. Analysis of blood and several tissues revealed an elevated selenium content for all pigs. Histological lesions in the brain and the cervical lumbar/sacral spinal cord enlargements included endothelial proliferation, neuronal degeneration, microcavitation and glial cell reaction.

将亚硒酸钠（以每千克体重1.4毫克、2.6毫克和4.2毫克的剂量封装）每日口服给予雄性断奶仔猪，并将这些动物的特征与对照组进行比较。在治疗开始后的3至20天内，所有实验组均出现了猪局灶性对称性脊髓软化症。对血液和多个组织的分析显示，所有猪的硒含量均升高。大脑以及颈腰椎/骶脊髓肿大处的组织学病变包括内皮细胞增殖、神经元变性、微空洞形成和胶质细胞反应。