Division of Pathophysiology, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Division of Pathophysiology, Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan,
Int Arch Allergy Immunol. 2021;182(6):535-545. doi: 10.1159/000512591. Epub 2021 Jan 25.
Eosinophilic chronic rhinosinusitis (ECRS) is a refractory chronic disease defined by recurrent nasal polyps with severe eosinophilic infiltration. This is mainly due to enhanced type 2-dominant immune responses, but the underlying mechanism is still not fully understood.
In the present study, we aimed to determine the characteristics of dendritic cells (DCs) and cytokine profiles of T cells in the peripheral blood of individuals with ECRS and age- and sex-matched healthy controls (HC).
The ratios of myeloid (m)DC1s to DCs and PD-L1+ mDC1s to mDC1s were higher in ECRS patients than in HC. The proportions of plasmacytoid (p)DCs in DCs, and human leukocyte antigen-DR+ pDCs and ILT3+ pDCs in pDCs were lower in ECRS patients than in HC. In a characterization of T cells, IL-4+CD4+, IFN-γ+CD4+, IL-4+IFN-γ+CD4+, IL-4+Foxp3+CD4+, IFN-γ+Foxp3+CD4+, IFN-γ+IL-4-Foxp3-CD4+, IL-4+CD8+, IL-4+IFN-γ+CD8+, and IL-4+Foxp3+CD8+ T-cell populations were significantly higher in ECRS patients than in HC. These results suggest that the enhanced immune regulation of mDC1, diminished capacity of pDCs, and increased proportion of the T-cell phenotypes in peripheral blood might be factors in ECRS pathogenesis.
嗜酸性慢性鼻-鼻窦炎（ECRS）是一种复发性疾病，其特征为反复出现的鼻息肉，伴有严重的嗜酸性粒细胞浸润。这主要是由于增强的 2 型主导免疫反应所致，但潜在机制仍不完全清楚。
在本研究中，我们旨在确定 ECRS 患者和年龄及性别匹配的健康对照（HC）外周血中树突状细胞（DC）和 T 细胞的细胞因子特征。
ECRS 患者的髓系（m）DC1 与 DC 之比和 PD-L1+mDC1 与 mDC1 之比高于 HC。DC 中浆细胞样（p）DC 比例、pDC 中人类白细胞抗原-DR+pDC 和 ILT3+pDC 比例均低于 HC。在 T 细胞特征方面，ECRS 患者的 IL-4+CD4+、IFN-γ+CD4+、IL-4+IFN-γ+CD4+、IL-4+Foxp3+CD4+、IFN-γ+Foxp3+CD4+、IFN-γ+IL-4-Foxp3-CD4+、IL-4+CD8+、IL-4+IFN-γ+CD8+和 IL-4+Foxp3+CD8+T 细胞群体显著高于 HC。这些结果表明，外周血中 mDC1 的增强免疫调节、pDC 功能的减弱以及 T 细胞表型比例的增加可能是 ECRS 发病机制的因素。
