Sato Tomoki, Kawaji Takahiro
Sato Eye and Internal Medicine Clinic, 4160-270 Arao, Arao City, Kumamoto 860-0041, Japan.
J Clin Med. 2021 Jan 21;10(3):401. doi: 10.3390/jcm10030401.
We evaluated the effects of ripasudil on the distal aqueous outflow tract in patients with open-angle glaucoma (OAG) who underwent a 360° suture trabeculotomy ab interno followed by ripasudil treatment beginning 1 month postoperatively. We compared 27 of these patients, by using propensity score analysis, with 27 patients in a matched control group who had no ripasudil treatment. We assessed the changes in the mean intraocular pressure (IOP) and the relationship between the IOP changes and background factors. All eyes had a complete 360° Schlemm's canal incision and phacoemulsification. The mean IOP at 1 and 3 months after ripasudil administration were significantly reduced by -1.7 ± 1.9 mmHg ( < 0.0001) and -1.3 ± 2.3 mmHg ( = 0.0081) in the ripasudil group, respectively, but IOP in the control group was not significantly reduced. The IOP reduction was significantly associated with the IOP before ripasudil treatment ( < 0.001). In conclusion, the use of ripasudil for patients with OAG after circumferential incision of the Schlemm's canal produced significant IOP reductions. Ripasudil may affect the distal outflow tract, thereby leading to the IOP reduction.
我们评估了ripasudil对接受360°内路小梁切开术且术后1个月开始ripasudil治疗的开角型青光眼（OAG）患者远端房水流出通道的影响。我们通过倾向评分分析，将其中27例患者与27例未接受ripasudil治疗的匹配对照组患者进行比较。我们评估了平均眼压（IOP）的变化以及IOP变化与背景因素之间的关系。所有眼睛均进行了完整的360°施莱姆管切开术和超声乳化术。ripasudil组在ripasudil给药后1个月和3个月时的平均IOP分别显著降低了-1.7±1.9 mmHg（P<0.0001）和-1.3±2.3 mmHg（P=0.0081），但对照组的IOP没有显著降低。IOP降低与ripasudil治疗前的IOP显著相关（P<0.001）。总之，在施莱姆管环形切开术后，ripasudil用于OAG患者可显著降低IOP。Ripasudil可能影响远端流出通道，从而导致IOP降低。
