Gomez-Casati Diego F, Busi Maria V, Barchiesi Julieta, Pagani Maria A, Marchetti-Acosta Noelia S, Terenzi Agustina
Centro de Estudios Fotosintéticos y Bioquímicos (CEFOBI-CONICET), Universidad Nacional de Rosario, Rosario 2000, Argentina.
Plants (Basel). 2021 Jan 21;10(2):200. doi: 10.3390/plants10020200.
Iron and sulfur are two essential elements for all organisms. These elements form the Fe-S clusters that are present as cofactors in numerous proteins and protein complexes related to key processes in cells, such as respiration and photosynthesis, and participate in numerous enzymatic reactions. In photosynthetic organisms, the ISC and SUF Fe-S cluster synthesis pathways are located in organelles, mitochondria, and chloroplasts, respectively. There is also a third biosynthetic machinery in the cytosol (CIA) that is dependent on the mitochondria for its function. The genes and proteins that participate in these assembly pathways have been described mainly in bacteria, yeasts, humans, and recently in higher plants. However, little is known about the proteins that participate in these processes in algae. This review work is mainly focused on releasing the information on the existence of genes and proteins of green algae (chlorophytes) that could participate in the assembly process of Fe-S groups, especially in the mitochondrial ISC and CIA pathways.
铁和硫是所有生物必需的两种元素。这些元素形成铁硫簇，作为辅因子存在于许多与细胞关键过程相关的蛋白质和蛋白质复合物中，如呼吸作用和光合作用，并参与众多酶促反应。在光合生物中，ISC和SUF铁硫簇合成途径分别位于细胞器、线粒体和叶绿体中。细胞质中还有第三种生物合成机制（CIA），其功能依赖于线粒体。参与这些组装途径的基因和蛋白质主要在细菌、酵母、人类中有所描述，最近在高等植物中也有报道。然而，对于藻类中参与这些过程的蛋白质知之甚少。这项综述工作主要集中于公布绿藻（绿藻门）中可能参与铁硫基团组装过程的基因和蛋白质的信息，特别是在线粒体ISC和CIA途径中的信息。
