Network of Dermatology Research (NDR), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Center for Research & Training in Skin Diseases & Leprosy, Tehran University of Medical Sciences, Tehran, Iran.
Immunol Invest. 2022 May;51(4):1087-1094. doi: 10.1080/08820139.2021.1876086. Epub 2021 Jan 26.
Coronavirus disease 2019 (COVID-19) mainly affects the respiratory system, but the involvement of other organ systems has also been commonly reported. Acute acro-ischemia or chilblain like lesions were among the first recognized dermatological presentations of COVID-19. Though the occurrence of such lesions has been attributed to the similar interferon-1 mediated immune response in both COVID-19 and systemic lupus erythematosus, we propose another possible explanation based on a common genetic background. In a recent genome-wide association study, the 3p21.31 region was found to be associated with COVID-19 severity. This region also contains the gene. Missense mutations of the gene are responsible for familial chilblain lupus and its genetic polymorphisms have been implicated in the pathogenesis of systemic lupus erythematosus. Based on this observation, herein we have reviewed other COVID-19 risk loci for potential overlap with dermatological conditions.
新型冠状病毒病 2019（COVID-19）主要影响呼吸系统，但也有报道称其他器官系统也受到了影响。急性肢端缺血或冻疮样病变是 COVID-19 最早被识别的皮肤科表现之一。虽然这些病变的发生被归因于 COVID-19 和系统性红斑狼疮中类似的干扰素-1 介导的免疫反应，但我们基于共同的遗传背景提出了另一种可能的解释。在最近的全基因组关联研究中，发现 3p21.31 区域与 COVID-19 的严重程度有关。该区域还包含 基因。 基因的错义突变导致家族性冻疮样狼疮，其遗传多态性与系统性红斑狼疮的发病机制有关。基于这一观察结果，我们在此回顾了其他与 COVID-19 风险相关的基因座，以寻找与皮肤科疾病的潜在重叠。
