Wang Allison B, Housley Stephen N, Flores Ann Marie, Kircher Sheetal M, Perreault Eric J, Cope Timothy C
Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, USA.
J Neuroeng Rehabil. 2021 Jan 25;18(1):16. doi: 10.1186/s12984-021-00818-2.
Chemotherapy agents used in the standard treatments for many types of cancer are neurotoxic and can lead to lasting sensory and motor symptoms that compromise day-to-day movement functions in cancer survivors. To date, the details of movement disorders associated with chemotherapy are known largely through self-reported symptoms and functional limitations. There are few quantitative studies of specific movement deficits, limiting our understanding of dysfunction, as well as effective assessments and interventions. The aim of this narrative review is to consolidate the current understanding of sensorimotor disabilities based on quantitative measures in cancer survivors who received chemotherapy. We performed literature searches on PubMed and found 32 relevant movement studies. We categorized these studies into three themes based on the movement deficits investigated: (1) balance and postural control; (2) gait function; (3) upper limb function. This literature suggests that cancer survivors have increased postural sway, more conservative gait patterns, and suboptimal hand function compared to healthy individuals. More studies are needed that use objective measures of sensorimotor function to better characterize movement disabilities and investigate the underlying causes, as required for developing targeted assessments and interventions. By updating our understanding of movement impairments in this population, we identify significant gaps in knowledge that will help guide the direction of future research.
用于多种癌症标准治疗的化疗药物具有神经毒性，可导致持久的感觉和运动症状，影响癌症幸存者的日常运动功能。迄今为止，与化疗相关的运动障碍细节主要通过自我报告的症状和功能限制得知。针对特定运动缺陷的定量研究很少，这限制了我们对功能障碍的理解以及有效的评估和干预措施。本叙述性综述的目的是基于对接受化疗的癌症幸存者的定量测量，巩固目前对感觉运动障碍的理解。我们在PubMed上进行了文献检索，发现了32项相关的运动研究。我们根据所研究的运动缺陷将这些研究分为三个主题：（1）平衡和姿势控制；（2）步态功能；（3）上肢功能。该文献表明，与健康个体相比，癌症幸存者的姿势摆动增加、步态模式更保守且手部功能欠佳。需要更多使用感觉运动功能客观测量方法的研究，以更好地表征运动障碍并调查潜在原因，这是制定有针对性的评估和干预措施所必需的。通过更新我们对该人群运动损伤的理解，我们发现了知识上的重大差距，这将有助于指导未来的研究方向。
