Lopes-Júnior Luís Carlos, Grassi Jonathan, Freitas Marcela Bortoleto, Trigo Fernanda Ercília Souza, Jardim Fabrine Aguilar, Nunes Karolini Zuqui, Vasconcelos Karla Anacleto de, Lima Regina Aparecida Garcia de
Graduate Program in Nutrition and Health, Health Sciences Center at the Federal University of Espírito Santo (UFES), Vitória 29040-091, ES, Brazil.
Graduate Program in Public Health, Health Sciences Center at the Federal University of Espírito Santo (UFES), Vitória 29040-091, ES, Brazil.
Nurs Rep. 2025 May 7;15(5):163. doi: 10.3390/nursrep15050163.
To synthesize and analyze the prevalence, composition, longitudinal stability, and predictors of cancer symptom clusters in children and adolescents undergoing chemotherapy. A systematic literature review was conducted in accordance with the PRISMA 2020 guidelines. Evidence was sourced from MEDLINE/PubMed, Cochrane Library, Embase, PsycINFO, and Web of Science, as well as clinical trial registries (Clinical Trials WHO-ICTRP) and gray literature. The search was performed in February 2025, with no restrictions on publication date or language. Two independent reviewers screened and selected the studies. The methodological quality of the included studies was assessed using design-specific tools, and the findings were synthesized narratively. A total of 6221 records were identified, with 12 studies meeting the inclusion criteria. These studies were published between 2010 and 2024 in the United States, Brazil, China, and Turkey. Cancer symptom clusters in children and adolescents followed well-defined patterns, with the gastrointestinal, emotional, fatigue-related, somatic, and self-image clusters being the most prevalent. Early identification of these cancer symptom clusters is essential for guiding interprofessional teams in delivering personalized, evidence-based care to children and adolescents with cancer and their families.
综合分析接受化疗的儿童和青少年癌症症状群的患病率、构成、纵向稳定性及预测因素。按照PRISMA 2020指南进行了系统的文献综述。证据来源于MEDLINE/PubMed、Cochrane图书馆、Embase、PsycINFO和Web of Science，以及临床试验注册库（世界卫生组织国际临床试验注册平台）和灰色文献。检索于2025年2月进行，对出版日期和语言无限制。两名独立评审员筛选并选定了这些研究。使用特定设计的工具评估纳入研究的方法学质量，并对研究结果进行叙述性综合分析。共识别出6221条记录，其中12项研究符合纳入标准。这些研究于2010年至2024年期间在美国、巴西、中国和土耳其发表。儿童和青少年的癌症症状群呈现出明确的模式，其中胃肠道、情绪、疲劳相关、躯体和自我形象症状群最为常见。早期识别这些癌症症状群对于指导跨专业团队为患癌儿童和青少年及其家庭提供个性化的循证护理至关重要。
