Transfusion Medicine, Children's National Hospital, 111 Michigan Avenue Northwest, Laboratory Administration, Suite 2100, Washington, DC 20010, USA.
Pathology and Laboratory Medicine Division, Transfusion Medicine, Children's National Hospital, 111 Michigan Avenue Northwest, Laboratory Administration, Suite 2100, Washington, DC 20010, USA.
Clin Lab Med. 2021 Mar;41(1):1-14. doi: 10.1016/j.cll.2020.10.001.
Children require transfusion of blood components for a vast array of medical conditions, including acute hemorrhage, hematologic and nonhematologic malignancies, hemoglobinopathy, and allogeneic and autologous stem cell transplant. Evidence-based literature on pediatric transfusion practices is limited, particularly for non-red blood cell products, and many recommendations are extrapolated from studies in adult populations. Recognition of these knowledge gaps has led to increasing numbers of clinical trials focusing on children and establishment of pediatric transfusion working groups in recent years. This article reviews existing literature on pediatric transfusion therapy within the larger context of analogous data in adult populations.
儿童在许多医疗情况下需要输注血液成分，包括急性出血、血液系统和非血液系统恶性肿瘤、血红蛋白病以及异基因和自体干细胞移植。关于儿科输血实践的循证文献有限，特别是对于非红细胞产品，并且许多建议是从成人人群的研究中推断出来的。认识到这些知识空白导致近年来越来越多的临床试验集中在儿童身上，并成立了儿科输血工作组。本文综述了在成人人群中类似数据的大背景下，儿科输血治疗的现有文献。
