Sostin Nataliya, Hendrickson Jeanne E
Department of Laboratory Medicine, Yale University, New Haven, CT, USA; Department of Pediatrics, Yale University, New Haven, CT, USA.
Department of Laboratory Medicine, Yale University, New Haven, CT, USA; Department of Pediatrics, Yale University, New Haven, CT, USA.
Clin Lab Med. 2021 Mar;41(1):51-67. doi: 10.1016/j.cll.2020.10.004. Epub 2020 Dec 23.
Some types of transfusion reactions occur more frequently in the pediatric than the adult population. Allergic reactions are the most common, followed by nonhemolytic transfusion reactions; male children seem most susceptible to such reactions. Platelets are often implicated and pulmonary reactions are understudied in children. Clinical sequelae in neonates, such as bronchopulmonary dysplasia/chronic lung disease and intraventricular hemorrhage, have received increasing attention in relation to transfusion. There is a need to better understand the pathophysiology of transfusion reactions in neonatal and pediatric populations so preventive strategies can be undertaken. There is also a need for robust hemovigilance systems.
某些类型的输血反应在儿科人群中比成人更常见。过敏反应最为常见，其次是非溶血性输血反应；男童似乎最易发生此类反应。血小板常与之相关，而儿童肺部反应的研究较少。新生儿的临床后遗症，如支气管肺发育不良/慢性肺病和脑室内出血，在输血方面受到了越来越多的关注。有必要更好地了解新生儿和儿科人群输血反应的病理生理学，以便采取预防策略。还需要健全的血液警戒系统。
