Department of Pediatrics, Division of Pediatric Hematology Oncology, Ankara Bilkent City Hospital, Ankara, Turkiye.
Department of Pediatrics, Division of Pediatric Hematology Oncology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkiye.
Turk J Med Sci. 2024 Jul 16;54(5):924-929. doi: 10.55730/1300-0144.5869. eCollection 2024.
BACKGROUND/AIM: The transfusion of blood products is a life-saving clinical practice in patients with bleeding, hemoglobinopathy, and cancer. It was aimed herein to analyze the frequency and types of blood component-related acute transfusion reactions (ATRs) in pediatric patients.
This retrospective study was conducted at a tertiary care academic pediatric hospital.
During the study period, 30,811 transfusions were administered to 25,448 patients. There were 103 ATRs detected in 81 patients (0.33%; 3.34 reactions per 1000 transfusions, mean age 8.3 ± 5.98 years, 36 females and 45 males). All the reactions were observed within an average of 4 h after the transfusion began. The most common ATRs were allergic reactions (79; 76.6%) and febrile nonhemolytic transfusion reactions (12; 11.6%). All the allergic transfusion reactions occurred within the first hour after the start of the transfusion. Granulocyte concentrates were the blood component associated with the highest ATR rate (2.1%).
Within our hospital, pediatric hematology-oncology wards and the stem cell transplantation unit had the most frequent ATR reports; therefore, when transfusions are carried out, increased attention should be given to these units. Educating health staff about the adverse effects of transfusion therapy should increase the awareness and reporting of ATRs in children.
背景/目的：在出血、血红蛋白病和癌症患者中，输血是一种救命的临床实践。本研究旨在分析儿科患者中与血液成分相关的急性输血反应（ATR）的频率和类型。
本回顾性研究在一家三级保健学术儿科医院进行。
在研究期间，对 25448 名患者输注了 30811 次血液。在 81 名患者中发现了 103 次 ATR（0.33%；每 1000 次输注发生 3.34 次反应，平均年龄 8.3 ± 5.98 岁，女性 36 名，男性 45 名）。所有反应均在输血开始后平均 4 小时内观察到。最常见的 ATR 是过敏反应（79 次；76.6%）和发热非溶血性输血反应（12 次；11.6%）。所有过敏输血反应均发生在输血开始后 1 小时内。粒细胞浓缩物与最高 ATR 率（2.1%）相关。
在我们医院，儿科血液科和干细胞移植病房的 ATR 报告最频繁；因此，在进行输血时，应特别注意这些病房。教育卫生人员有关输血治疗的不良反应应提高儿童 ATR 的意识和报告。
