Faden Alan I, Barrett James P, Stoica Bogdan A, Henry Rebecca J
Department of Anesthesiology and Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Department of Anesthesiology and Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Trends Neurosci. 2021 May;44(5):406-418. doi: 10.1016/j.tins.2020.12.004. Epub 2021 Jan 22.
Traumatic brain injury (TBI) is a debilitating disorder associated with chronic progressive neurodegeneration and long-term neurological decline. Importantly, there is now substantial and increasing evidence that TBI can negatively impact systemic organs, including the pulmonary, gastrointestinal (GI), cardiovascular, renal, and immune system. Less well appreciated, until recently, is that such functional changes can affect both the response to subsequent insults or diseases, as well as contribute to chronic neurodegenerative processes and long-term neurological outcomes. In this review, we summarize evidence showing bidirectional interactions between the brain and systemic organs following TBI and critically assess potential underlying mechanisms.
创伤性脑损伤（TBI）是一种使人衰弱的疾病，与慢性进行性神经退行性变和长期神经功能衰退相关。重要的是，现在有大量且不断增加的证据表明，TBI会对全身器官产生负面影响，包括肺、胃肠道（GI）、心血管、肾脏和免疫系统。直到最近，人们才较少认识到，这种功能变化不仅会影响对后续损伤或疾病的反应，还会导致慢性神经退行性过程和长期神经功能结局。在这篇综述中，我们总结了表明TBI后脑与全身器官之间双向相互作用的证据，并批判性地评估了潜在的潜在机制。
