危重症 COVID-19 患者中 Epstein-Barr 病毒、巨细胞病毒和人类疱疹病毒-6 再激活的发生率较高。
High incidence of Epstein-Barr virus, cytomegalovirus, and human-herpes virus-6 reactivations in critically ill patients with COVID-19.
机构信息
Pôle de réanimation, CHU de Lille, 59000 Lille, France.
Laboratoire de virologie ULR3610, université de Lille et CHU de Lille, 59000 Lille, France.
出版信息
Infect Dis Now. 2021 May;51(3):296-299. doi: 10.1016/j.idnow.2021.01.005. Epub 2021 Jan 18.
Abstract
BACKGROUND
Systemic reactivation of herpesviruses may occur in intensive care unit (ICU) patients and is associated with morbidity and mortality. Data on severe Coronavirus disease-19 (COVID-19) and concomitant reactivation of herpesviruses are lacking.
METHODS
We selected patients admitted to ICU for confirmed COVID-19 who underwent systematic testing for Epstein-Barr virus (EBV), cytomegalovirus (CMV) and human-herpes virus-6 (HHV-6) DNAemia while in the ICU. We retrospectively analysed frequency, timing, duration and co-occurrence of viral DNAemia.
RESULTS
Thirty-four patients were included. Viremia with EBV, CMV, and HHV-6 was detected in 28 (82%), 5 (15%), and 7 (22%) patients, respectively. EBV reactivation occurred early after ICU admission and was associated with longer ICU length-of-stay.
CONCLUSIONS
While in the ICU, critically ill patients with COVID-19 are prone to develop reactivations due to various types of herpesviruses.
摘要
背景
疱疹病毒的全身再激活可能发生在重症监护病房（ICU）的患者中，并与发病率和死亡率相关。关于严重的 2019 年冠状病毒病（COVID-19）和伴随的疱疹病毒再激活的数据尚缺乏。
方法
我们选择了因确诊 COVID-19 而入住 ICU 的患者，这些患者在 ICU 期间接受了系统的检测，以确定 Epstein-Barr 病毒（EBV）、巨细胞病毒（CMV）和人类疱疹病毒-6（HHV-6）的 DNA 血症。我们回顾性分析了病毒血症的频率、时间、持续时间和共同发生情况。
结果
共纳入 34 名患者。28 名（82%）、5 名（15%）和 7 名（22%）患者分别检测到 EBV、CMV 和 HHV-6 的病毒血症。EBV 的再激活发生在 ICU 入院后早期，与 ICU 住院时间延长有关。
结论
入住 ICU 的危重症 COVID-19 患者容易因各种类型的疱疹病毒而发生再激活。
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