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长新冠:一项概念分析。

Long COVID-19: A Concept Analysis.

作者信息

Srikanth Sujata, Boulos Jessica R, Ivankovic Diana, Gonzales Lucia, Dean Delphine, Boccuto Luigi

机构信息

Center for Innovative Medical Devices and Sensors (REDDI Lab), Clemson University, Clemson, SC 29634, USA.

School of Nursing, College of Behavioral, Social and Health Sciences, Clemson University, Clemson, SC 29634, USA.

出版信息

Infect Dis Rep. 2025 Jul 29;17(4):90. doi: 10.3390/idr17040090.

DOI:10.3390/idr17040090
PMID:40863252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12386072/
Abstract

: In late 2019, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) caused a pandemic called the 'coronavirus disease 2019' (COVID-19). After the acute SARS-CoV-2 infection, many individuals (up to 33%) complained of unexplained symptoms involving multiple organ systems and were diagnosed as having Long COVID-19 (LC-19). Currently, LC-19 is inadequately defined, requiring the formation of consistent diagnostic parameters to provide a foundation for ongoing and future studies of epidemiology, risk factors, clinical characteristics, and therapy. LC-19 represents a significant burden on multiple levels. The reduced ability of workers to return to work or compromised work efficiency has led to consequences at national, economic, and societal levels by increasing dependence on community services. On a personal scale, the isolation and helplessness caused by the disease and its subsequent impact on the patient's mental health and quality of life are incalculable. : In this paper, we used Walker and Avants' eight-step approach to perform a concept analysis of the term "Long COVID-19" and define its impact across these parameters. : Using this methodology, we provide an improved definition of LC-19 by connecting the clinical symptomology with previously under-addressed factors, such as mental, psychological, economic, and social effects. This definition of LC-19 features can help improve diagnostic procedures and help plan relevant healthcare services. : LC-19 represents a complex and pressing public health challenge with diverse symptomology, an unpredictable timeline, and complex pathophysiology. This concept analysis serves as a tool for improving LC-19 definition, but it remains a dynamic disease with evolving diagnostic and therapeutic approaches, requiring deeper investigation and understanding of its long-term effects.

摘要

2019年末,严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引发了一场名为“2019冠状病毒病”(COVID-19)的全球大流行。在急性SARS-CoV-2感染后,许多人(高达33%)抱怨出现涉及多个器官系统的不明症状,并被诊断为患有长期新冠(LC-19)。目前,LC-19的定义尚不明确,需要形成一致的诊断参数,为正在进行的以及未来关于流行病学、风险因素、临床特征和治疗的研究提供基础。LC-19在多个层面造成了重大负担。工人复工能力下降或工作效率受损,导致对社区服务的依赖增加,从而在国家、经济和社会层面产生了后果。在个人层面,疾病造成的隔离和无助及其对患者心理健康和生活质量的后续影响是难以估量的。本文采用沃克和阿万茨的八步法对“长期新冠”一词进行概念分析,并界定其在这些参数方面的影响。通过这种方法,我们将临床症状学与之前未充分探讨的因素(如心理、经济和社会影响)联系起来,从而对LC-19给出了一个改进的定义。LC-19的这一定义特征有助于改进诊断程序,并有助于规划相关的医疗服务。LC-19是一个复杂而紧迫的公共卫生挑战,其症状多样、病程不可预测且病理生理学复杂。这一概念分析是改进LC-19定义的工具,但它仍然是一种动态疾病,其诊断和治疗方法不断演变,需要对其长期影响进行更深入的研究和理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2630/12386072/889fdd658a08/idr-17-00090-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2630/12386072/889fdd658a08/idr-17-00090-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2630/12386072/889fdd658a08/idr-17-00090-g001.jpg

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本文引用的文献

1
Genome-wide association study of long COVID.长期新冠的全基因组关联研究
Nat Genet. 2025 May 21. doi: 10.1038/s41588-025-02100-w.
2
Impact of pre-existing comorbidities and multimorbidities, demography and viral variants on post-acute sequelae of COVID-19 ('Long COVID') in Dutch primary care: A retrospective cohort study.荷兰初级医疗保健中,既往合并症和多种合并症、人口统计学因素及病毒变体对新冠后遗症(“长新冠”)的影响:一项回顾性队列研究
Int J Infect Dis. 2025 Jul;156:107912. doi: 10.1016/j.ijid.2025.107912. Epub 2025 Apr 19.
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Follow-up of long COVID based on the definition of WHO: a multi-centre cross-sectional questionnaire-based study.
基于世界卫生组织定义的新冠后症状长期随访:一项多中心横断面问卷调查研究
BMC Public Health. 2025 Apr 15;25(1):1412. doi: 10.1186/s12889-025-22671-x.
4
LC risk score - development and evaluation of a scale for assessing the risk of developing long COVID.长新冠风险评分——一种评估发生长新冠风险的量表的开发与评估
Arch Med Sci. 2024 Apr 21;21(1):121-130. doi: 10.5114/aoms/187781. eCollection 2025.
5
Neuropsychiatric Manifestations of Long COVID-19: A Narrative Review of Clinical Aspects and Therapeutic Approaches.长新冠的神经精神表现:临床方面与治疗方法的叙述性综述
Life (Basel). 2025 Mar 11;15(3):439. doi: 10.3390/life15030439.
6
Association between Mexican vaccination schemes and the duration of long COVID syndrome symptoms.墨西哥疫苗接种方案与新冠后综合征症状持续时间之间的关联。
Sci Rep. 2025 Feb 12;15(1):5301. doi: 10.1038/s41598-024-59954-z.
7
Prevalence of cardiovascular symptoms in post-acute COVID-19 syndrome: a meta-analysis.急性 COVID-19 综合征后心血管症状的患病率:一项荟萃分析。
BMC Med. 2025 Feb 6;23(1):70. doi: 10.1186/s12916-025-03908-3.
8
The Relationship Between Long Covid Symptoms and Vaccination Status in COVID-19 Survivors.新冠康复者中长新冠症状与疫苗接种状况的关系
J Eval Clin Pract. 2025 Feb;31(1):e70004. doi: 10.1111/jep.70004.
9
The Current and Future Burden of Long COVID in the United States (U.S.).美国长期新冠的当前及未来负担
J Infect Dis. 2025 Jan 22. doi: 10.1093/infdis/jiaf030.
10
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Front Immunol. 2024 Dec 3;15:1450853. doi: 10.3389/fimmu.2024.1450853. eCollection 2024.