Pediatric Dentistry Postgraduate Program, Faculty of Dentistry, San Luis Potosi University, 2 Manuel Nava, Zona Universitaria, 78290, San Luis Potosí, SLP, Mexico.
Endodontics Posgraduated Program, Faculty of Dentistry, San Luis Potosí University, San Luis Potosí, SLP, Mexico.
Odontology. 2021 Jul;109(3):687-695. doi: 10.1007/s10266-021-00591-7. Epub 2021 Jan 26.
The aims of this in vitro study were to synthesize, characterize, and evaluate the efficacy of a Calcium Hydroxide/Iodoform nanoparticles (CHIN) paste compared with Ultrapex as intracanal filling medication using an experimental model of bovine primary teeth. CH nanoparticle synthesis was performed via the simple hydrolysis technique of reacting calcium nitrate with sodium hydroxide. SEM-EDS and FT-IR analyses were used to characterize the obtained product. 30% of CH nanoparticles were combined with 40% of iodoform and 30% silicone oil to prepare an intracanal filling paste (CHIN). All endodontic procedures were performed on 34 uniradicular primary bovine teeth. Every root canal was instrumented with K files (up to #35) and obturated with the nanoparticle paste (experimental) or Ultrapex (control). Three outcome variables were studied: penetration depth through the root dentinal tubules, Ca ion release, and filling paste dissolution rate. The obtained data were analyzed by Student's t test. The X-ray diffraction pattern of CH nanoparticles showed characteristic peaks at CH, as confirmed by FT-IR analyses in which an intense signal was observed at 3643 cm, characteristic of CH. In the morphological characterization, CH particles could be detected at the nanosize scale. When applied as intracanal filling, the CHIN paste exhibited a higher level of penetration through the root dentin tubules. The global mean penetration measures were 500 µm for the experimental paste and 380 µm for the control paste (p < 0.05). The release of Ca ions (up to the seventh day) and the dissolution rate were significantly higher in the experimental paste group than in the control group. No significant differences were observed between the groups regarding pH levels. The findings of this study suggest the potential suitability of CHI nanoparticles as an alternative intracanal filling medication for infected or devitalized primary teeth.
本体外研究的目的是合成、表征并评估一种氢氧化钙/碘仿纳米粒子（CHIN）糊剂与 Ultrapex 相比作为根管内填充药物的疗效，使用牛初级牙齿的实验模型。CH 纳米粒子的合成是通过钙硝酸盐与氢氧化钠的简单水解技术进行的。SEM-EDS 和 FT-IR 分析用于表征所得产物。将 30%的 CH 纳米粒子与 40%的碘仿和 30%的硅油结合制备根管内填充糊剂（CHIN）。所有根管治疗程序均在 34 颗单根牛初级牙齿上进行。每个根管均用 K 文件（最多至 #35）进行器械处理，并使用纳米粒子糊剂（实验组）或 Ultrapex（对照组）进行堵塞。研究了三个结果变量：通过根管牙本质小管的穿透深度、Ca 离子释放和填充糊剂溶解率。通过 Student's t 检验分析所得数据。CH 纳米粒子的 X 射线衍射图谱显示在 CH 处有特征峰，这通过 FT-IR 分析得到证实，其中在 3643 cm 处观察到 CH 的特征强信号。在形态学表征中，可以在纳米尺寸范围内检测到 CH 颗粒。当用作根管内填充时，CHIN 糊剂在穿过根管牙本质小管方面表现出更高的穿透水平。实验组的总平均穿透测量值为 500 µm，对照组为 380 µm（p<0.05）。实验组中 Ca 离子的释放（直至第 7 天）和溶解率显著高于对照组。两组的 pH 值没有显著差异。本研究的结果表明，CHI 纳米粒子作为感染或失活的初级牙齿的替代根管内填充药物具有潜在的适用性。
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