Kemeny D M, Kagey-Sobotka A, Lichtenstein L M, Lessof M H
Department of Medicine, United Medical, Schools, Guy's Hospital, London, U.K.
Clin Allergy. 1988 Jan;18(1):79-84. doi: 10.1111/j.1365-2222.1988.tb02846.x.
The immunological response to individual bee-venom allergens was studied in blood samples collected at frequent intervals from four bee-venom allergic patients who had suffered systemic allergic reactions to injections of bee venom during immunotherapy. All had high IgE antibody levels, at the upper end of the range found in bee-sting allergic patients, and all had antibodies to the minor allergens at the time of the reactions. These did not, however, provide a simple explanation for the reactions that occurred. We were able to observe two interesting phenomena--in one patient IgE antibodies to the individual venom antigens appeared to be 'switched off' sequentially. In another, IgE antibodies to hyaluronidase rose substantially after 4 years of therapy. We believe that these results provide evidence to support the view that the regulation of IgE antibodies is controlled by mechanisms that are both isotype- and antigen-specific.
对4名在免疫治疗期间因注射蜂毒而发生全身过敏反应的蜂毒过敏患者，每隔一段时间采集血样，研究其对单个蜂毒过敏原的免疫反应。所有患者的IgE抗体水平都很高，处于蜂蜇过敏患者中发现的范围上限，并且在反应发生时都有针对次要过敏原的抗体。然而，这些并不能为所发生的反应提供简单的解释。我们观察到两个有趣的现象——在一名患者中，针对单个毒液抗原的IgE抗体似乎依次“关闭”。在另一名患者中，经过4年治疗后，针对透明质酸酶的IgE抗体大幅上升。我们认为，这些结果为支持IgE抗体的调节受同种型和抗原特异性机制控制这一观点提供了证据。
