Department of Rheumatology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongti South Road, Chaoyang District, Beijing, 100020, China.
Clin Rheumatol. 2021 Aug;40(8):3345-3350. doi: 10.1007/s10067-021-05596-9. Epub 2021 Jan 25.
This study presents a rare case of pulmonary amyloidosis and cystic lung disease associated with primary Sjögren's syndrome. In February 2019, a 76-year-old woman with primary Sjögren's syndrome presented to our rheumatology department for lung problems. Four years before presentation, the patient underwent chest computed tomography that revealed multiple nodules with numerous thin-walled lumen in both lungs. Pulmonary nodulectomy for hemoptysis was performed 2 years before presentation. Pathological findings suggested chronic inflammation of the bronchus and amyloid deposition in the lung tissue. The nodules and vesicles were generally larger from January 2015 to October 2018 when she did not receive any special medication, but the nodules and vesicles tended to be stable from February to August 2019 when she was treated with hydroxychloroquine sulfate regularly, suggesting that hydroxychloroquine sulfate may be helpful in this patient.
本研究报告了一例罕见的原发性干燥综合征相关肺淀粉样变性和囊性肺疾病。2019 年 2 月，一位 76 岁的原发性干燥综合征女性患者因肺部问题到我院风湿科就诊。在就诊前 4 年，患者行胸部 CT 检查提示双肺多发含多个薄壁腔的结节。就诊前 2 年因咯血行肺结节切除术。病理结果提示支气管慢性炎症和肺组织内的淀粉样物质沉积。2015 年 1 月至 2018 年 10 月，患者未接受任何特殊药物治疗时，结节和囊泡一般较大，但 2019 年 2 月至 8 月患者接受硫酸羟氯喹规律治疗时，结节和囊泡趋于稳定，提示硫酸羟氯喹可能对该患者有益。
