Department of Internal Medicine, Division of Rheumatology, Ege University Faculty of Medicine, Izmir, Turkey.
Department of Pathology, Ege University Faculty of Medicine, Izmir, Turkey.
Int J Rheum Dis. 2023 Dec;26(12):2563-2566. doi: 10.1111/1756-185X.14753. Epub 2023 Jun 9.
There are very few cases in the literature on the coexistence of Sjögren's syndrome and pulmonary nodular amyloidosis being treated with rituximab. When nodules with central calcification and cystic lesions are seen on computed tomography, amyloid lung should be considered. Biopsy is recommended as it can be confused with malignancies. In this article, we present a 66-year-old female patient who has been followed up for Sjögren's syndrome for 26 years. Multiple cystic lesions with central calcification in the lung were detected and it was evaluated as amyloid nodule in the biopsy performed. The patient is being followed and is stable under rituximab treatment. Pulmonary noduler amyloidosis is very rare in Sjögren patients and there are very few cases where rituximab is used for treatment. We decided to publish in order to guide clinicians who will encounter similar cases.
文献中很少有关于干燥综合征合并肺结节状淀粉样变性并用利妥昔单抗治疗的病例报道。当 CT 上见到中央钙化和囊性病变的结节时，应考虑淀粉样肺。建议进行活检，因为它可能与恶性肿瘤相混淆。本文介绍了一位 66 岁的女性患者，她患有干燥综合征已有 26 年的病史。肺部发现多个中央钙化的囊性病变，活检评估为淀粉样结节。患者正在接受随访，并在利妥昔单抗治疗下病情稳定。肺结节状淀粉样变性在干燥综合征患者中非常罕见，用利妥昔单抗治疗的病例也很少。我们决定发表这篇文章，以便为遇到类似病例的临床医生提供指导。
