短期紫外线照射对接触性超敏反应的抑制作用：I. 来自受照射小鼠血清的免疫抑制作用
Suppression of contact hypersensitivity by short-term ultraviolet irradiation: I. Immunosuppression by serum from irradiated mice.
作者信息
Harriott-Smith T G, Halliday W J
机构信息
Microbiology Department, University of Queensland, Australia.
出版信息
Clin Exp Immunol. 1988 Jan;71(1):144-8.
Serum from UV-irradiated mice was shown to be immunosuppressive in vitro and in vivo. It suppressed leucocyte adherence inhibition reactions of cells from sensitized syngeneic and allogeneic mice, and suppressed the development of contact hypersensitivity after passive transfer to mice. Supernatants of cultures of spleen cells from irradiated mice were also suppressive. The suppressive factors in sera and culture supernatants were non-dialysable. The suppressive effect of UV irradiation was abrogated by cyclophosphamide, but this restored reactivity was still inhibited by serum from irradiated donors; this suggests that the serum factor requires T suppressor cells for its production but not for its action. The level of interleukin 1 (IL-1) was not raised in serum from UV-irradiated mice; thus the serum factor appears not to be IL-1.
紫外线照射小鼠的血清在体内外均表现出免疫抑制作用。它抑制了来自致敏同基因和异基因小鼠细胞的白细胞黏附抑制反应，并在被动转移到小鼠后抑制了接触性超敏反应的发展。照射小鼠脾细胞培养上清液也具有抑制作用。血清和培养上清液中的抑制因子不可透析。环磷酰胺可消除紫外线照射的抑制作用，但这种恢复的反应性仍被照射供体的血清所抑制；这表明血清因子的产生需要T抑制细胞，但发挥作用不需要。紫外线照射小鼠的血清中白细胞介素1（IL-1）水平未升高；因此血清因子似乎不是IL-1。
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