用于成像和癌症治疗的硫化氢触发分子剂。
Hydrogen sulfide triggered molecular agent for imaging and cancer therapy.
作者信息
Ge Chao, Di Xiaojiao, Han Siqi, Wang Mengmeng, Qian Xiaoting, Su Zhi, Liu Hong-Ke, Qian Yong
机构信息
School of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Nanjing Normal University, Nanjing, 210023, P. R. China.
Department of Medical Oncology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, 210002, P. R. China and Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, 210002, P. R. China.
出版信息
Chem Commun (Camb). 2021 Feb 23;57(15):1931-1934. doi: 10.1039/d0cc07982k.
We developed an activatable molecular reagent, PNF, triggered by intracellular H2S in the lysosome to release the therapeutic drug amonafide, which can escape from the lysosome into the nucleus to induce autophagy of cancer cells. PNF exhibits potent inhibitory activity against cisplatin-resistant tumor cell lines.
我们开发了一种可激活的分子试剂PNF，它由溶酶体中的细胞内硫化氢触发，以释放治疗药物氨苯甲酰，该药物可从溶酶体逃逸到细胞核中，从而诱导癌细胞自噬。PNF对顺铂耐药肿瘤细胞系表现出强大的抑制活性。
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