Akbari Sene Azadeh, Tahmasbi Bita, Keypour Farideh, Zamanian Hadi, Golbabaei Fahimeh, Amini-Tehrani Mohammadali
Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran.
Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran. Email:
Int J Fertil Steril. 2021 Jan;15(1):65-72. doi: 10.22074/ijfs.2021.6206. Epub 2021 Jan 19.
The aim of this study was to examine sexual function and its correlates among infertile women with polycystic ovary syndrome (PCOS) in comparison with their non-PCOS counterparts.
In this case-control study, 209 infertile women (116 PCOS and 93 non-PCOS) from Tehran, Iran, were evaluated in February and March 2018. Female sexual function index (FSFI), hormonal status, and documented reports of hyperandrogenic manifestations of the patients were investigated.
The mean age of the patients was 32.00 ± 5.00 years old. Eighty-four (40.2%) patients including 42.2% of the PCOS patients and 37.6% of the non-PCOS cases (P>0.05), were suspected of female sexual dysfunction (FSD). The most impaired functions in both groups were desire and arousal. Sexual function was not significantly different between the groups. However, PCOS women had more orgasm problems and acne worsened their sexual function. Total FSFI was positively associated with prolactin level but negatively associated with central obesity in the non-PCOS group; it was negatively correlated with marital duration in the PCOS group. Luteinizing hormone (LH) and pain, prolactin level and lubrication, and central obesity and arousal were correlated in the non-PCOS women. Prolactin level and orgasm, marital duration and arousal, and marital duration and the total FSFI were correlated in the PCOS women.
Sexual function was similarly low in infertile PCOS and non-PCOS women. However, orgasm problems and the negative effect of acne varied between the two groups. Further investigations may target how hormonal profile may affect sexual function. Practitioners should scrutinize the specific impaired sexual domains and their correlated conditions in PCOS women, notably orgasm, acne, and prolactin level. Interventions should be well tailored based on particular needs of infertile PCOS women.
本研究旨在比较多囊卵巢综合征（PCOS）不孕女性与其非PCOS不孕女性的性功能及其相关因素。
在这项病例对照研究中，2018年2月和3月对来自伊朗德黑兰的209名不孕女性（116名PCOS患者和93名非PCOS患者）进行了评估。调查了女性性功能指数（FSFI）、激素状态以及患者高雄激素表现的记录报告。
患者的平均年龄为32.00±5.00岁。84名（40.2%）患者，包括42.2%的PCOS患者和37.6%的非PCOS患者（P>0.05），被怀疑存在女性性功能障碍（FSD）。两组中受损最严重的功能是性欲和性唤起。两组之间的性功能无显著差异。然而，PCOS女性有更多的性高潮问题，痤疮会使其性功能恶化。在非PCOS组中，FSFI总分与催乳素水平呈正相关，但与中心性肥胖呈负相关；在PCOS组中，FSFI总分与婚姻持续时间呈负相关。在非PCOS女性中，促黄体生成素（LH）与疼痛、催乳素水平与润滑、中心性肥胖与性唤起之间存在相关性。在PCOS女性中，催乳素水平与性高潮、婚姻持续时间与性唤起、婚姻持续时间与FSFI总分之间存在相关性。
PCOS不孕女性和非PCOS不孕女性的性功能同样较低。然而，两组之间性高潮问题和痤疮的负面影响有所不同。进一步的研究可能针对激素谱如何影响性功能。从业者应仔细审查PCOS女性中特定受损的性功能领域及其相关状况，特别是性高潮、痤疮和催乳素水平。应根据PCOS不孕女性的特定需求进行针对性干预。
