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二尖瓣脱垂完全可修复:一种动态非切除技术的结果。

One Hundred Percent Reparability of Mitral Prolapse: Results of a Dynamic Nonresectional Technique.

机构信息

Department of Cardiovascular Surgery, Methodist DeBakey Heart Center, Houston Methodist Hospital, Houston, Texas.

Department of Cardiology, Methodist DeBakey Heart Center, Houston Methodist Hospital, Houston, Texas.

出版信息

Ann Thorac Surg. 2021 Dec;112(6):1921-1928. doi: 10.1016/j.athoracsur.2020.09.090. Epub 2021 Jan 23.

Abstract

BACKGROUND

We studied the results of a dynamic mitral repair technique that preserves normal mitral valve function by avoiding leaflet resection and rigid and semirigid annuloplasty rings.

METHODS

In previous reports we demonstrated that intraoperative simulation of mitral valve locking and isovolumic systole by rapid left ventricular inflation with pressurized saline accurately simulates mitral annular and leaflet shape and position, and left ventricular outflow tract dimensions. Length of polytetrafluoroethylene neochordae and size of fully flexible adjustable annuloplasty ring can be adjusted in three dimensions for accurate apposition of zones of leaflet coaptation, premarked with dots. We followed 1068 consecutive patients after repairs performed between 2001 and 2018.

RESULTS

Of the 1068 patients, 674 were men (63.1%). Mean age was 62.25 ± 13 years. Leaflet repaired was anterior in 118 patients (11.05%), posterior in 564 (52.81%), both in 55 (5.15%), and neither in 123 (11.5%). Barlow's disease was present in 208 patients (19.48%). Repair was isolated in 82.5% (881 of 1068). Reparability was 100%. Perioperative mortality overall was 1.59% (17 of 1068): isolated repair, 1.14% (10 of 881); and isolated posterior leaflet, 0.85% (4 of 472). Leaflet systolic anterior motion occurred in 1.7% (18 of 1068), and was significant in 0.4% (4 of 1068). Survival at 10 years by Kaplan-Meier analysis was 74.65%, freedom from reoperation was 96.01%, and freedom from severe mitral regurgitation was 94%. The only predictor of reoperation (Cox analysis) was being male (P = .001).

CONCLUSIONS

Use of intraoperative simulation of mitral dynamics led to 100% reparability for degenerative valves with minimal systolic anterior motion, despite no leaflet resection. Long-term durability has been good and similar for all leaflets.

摘要

背景

我们研究了一种通过避免瓣叶切除和刚性及半刚性瓣环成形术来保留二尖瓣正常功能的二尖瓣修复技术的结果。

方法

在之前的报告中,我们证明了通过快速向左心室注入加压生理盐水使二尖瓣锁定和等容收缩期模拟,可以准确模拟二尖瓣瓣环和瓣叶的形状和位置,以及左心室流出道的尺寸。聚四氟乙烯新腱索的长度和完全可调节的环形成形术环的尺寸可以在三维空间中进行调整,以准确贴合预先标记为点的瓣叶对合区。我们对 2001 年至 2018 年期间进行的修复手术后的 1068 例连续患者进行了随访。

结果

在 1068 例患者中,674 例为男性(63.1%)。平均年龄为 62.25 ± 13 岁。前瓣叶修复 118 例(11.05%),后瓣叶修复 564 例(52.81%),双瓣叶修复 55 例(5.15%),无瓣叶修复 123 例(11.5%)。Barlow 病 208 例(19.48%)。单纯修复 82.5%(881 例)。可修复性为 100%。总体围手术期死亡率为 1.59%(1068 例中有 17 例):单纯修复为 1.14%(881 例中有 10 例);单纯后瓣叶修复为 0.85%(472 例中有 4 例)。1068 例中有 1.7%(18 例)发生瓣叶收缩期前运动,其中 0.4%(4 例)为显著运动。Kaplan-Meier 分析显示 10 年生存率为 74.65%,无再手术率为 96.01%,无严重二尖瓣反流率为 94%。再手术的唯一预测因素(Cox 分析)是男性(P =.001)。

结论

尽管未进行瓣叶切除,但使用二尖瓣动力学的术中模拟可实现 100%的可修复性,且二尖瓣收缩期前运动最小。长期耐久性良好,所有瓣叶相似。

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