School of Mechanical Engineering, Shandong University, Jinan, 250061, China.
School of Mechanical Engineering, Shandong University, Jinan, 250061, China.
Neurosci Lett. 2021 Feb 16;746:135668. doi: 10.1016/j.neulet.2021.135668. Epub 2021 Jan 23.
This study aims to explore the age-related changes in cerebral cortex activation and functional connectivity (FC) during finger-to-thumb opposition movement based on video games (FTOMBVG).
A electronic fingercot was developed for FTOMBVG. The oxygenated hemoglobin concentration (Delta [HbO]) signals, measured by functional near-infrared spectroscopy (fNIRS), were recorded from prefrontal cortex (PFC), motor cortex (MC) and occipital lobe (OL) of two groups of subjects (old and young).
The cognitive region of the old group showed bilateral activation, while the young group only showed unilateral activation. Both groups showed a wide range of bilateral activation in the motor region. The FC between cognitive region and motor region of the old group was enhanced considerably.
Changes in cerebral cortex activation and the FC of different brain regions in the old group help explain the decline in cognitive executive and motor control function in the old from the perspective of brain functional structure, and provide a theoretical reference for the prevention of neural diseases caused by aging.
本研究旨在通过基于视频游戏的手指对拇指运动（FTOMBVG），探索大脑皮层在进行手指对拇指运动时激活和功能连接（FC）随年龄的变化。
为 FTOMBVG 开发了电子指套。通过功能近红外光谱（fNIRS）记录来自前额叶皮层（PFC）、运动皮层（MC）和枕叶（OL）的两组受试者（老年和年轻）的含氧血红蛋白浓度（Delta [HbO]）信号。
老年组的认知区表现为双侧激活，而年轻组仅表现为单侧激活。两组在运动区均表现出广泛的双侧激活。老年组认知区与运动区之间的 FC 明显增强。
老年组大脑皮层激活和不同脑区 FC 的变化，从脑功能结构的角度有助于解释老年人认知执行和运动控制功能的下降，并为预防因衰老引起的神经疾病提供理论参考。
