口服肽递药的新视角。
New perspectives in oral peptide delivery.
机构信息
Center of Organic and Medicinal Chemistry, Institute of Chemistry and Biotechnology, Zurich University of Applied Sciences ZHAW, Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland.
Center of Organic and Medicinal Chemistry, Institute of Chemistry and Biotechnology, Zurich University of Applied Sciences ZHAW, Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland.
出版信息
Drug Discov Today. 2021 Apr;26(4):1097-1105. doi: 10.1016/j.drudis.2021.01.020. Epub 2021 Jan 23.
Owing to their structural diversity, peptides are a unique source of innovative active ingredients. However, their development has been challenging because of their disadvantageous pharmacokinetic (PK) properties. Over the past decade, many attempts have been made to improve the oral bioavailability of peptide drugs. In this review, we highlight the most recent and promising techniques aimed at the improvement of the oral bioavailability of peptides. The most recent findings will influence future approaches of pharmaceutical companies in the development of new, more efficient, and safer orally delivered peptides.
由于其结构多样性，肽是创新活性成分的独特来源。然而，由于其不利的药代动力学（PK）特性，它们的开发一直具有挑战性。在过去的十年中，人们已经做出了许多尝试来提高肽类药物的口服生物利用度。在这篇综述中，我们重点介绍了旨在提高肽类口服生物利用度的最新和最有前途的技术。这些最新发现将影响制药公司在开发新的、更有效和更安全的口服肽类药物方面的未来方法。
Zotero 插件