Biology Centre, Czech Academy of Sciences, České Budějovice, Czech Republic; University of South Bohemia, Faculty of Science, České Budějovice, Czech Republic.
Max Planck Institute of Molecular Plant Physiology, Potsdam, Germany.
Curr Opin Plant Biol. 2021 Jun;61:102002. doi: 10.1016/j.pbi.2021.102002. Epub 2021 Jan 23.
Chromatin structure influences DNA accessibility and underlying gene expression. Disturbances of chromatin structure often result in pleiotropic developmental phenotypes. Interactions between chromatin modifications and development have been the main focus of epigenetic studies. Recent years brought major advance in uncovering and understanding connections between chromatin organisation in the nucleus and metabolic processes that take place in the cytoplasm or other cellular compartments. Products of primary metabolism and cell redox states influence chromatin-modifying complexes, and chromatin modifiers in turn affect expression of metabolic genes. Current evidence indicates that complex interaction loops between these biological system layers exist. Applying interdisciplinary and holistic approaches will decipher causality and molecular mechanisms of the dynamic crosstalk between chromatin structure, metabolism and plant growth and development.
染色质结构影响 DNA 的可及性和潜在的基因表达。染色质结构的紊乱常常导致多效性的发育表型。染色质修饰与发育之间的相互作用一直是表观遗传学研究的主要焦点。近年来，在揭示和理解核内染色质组织与发生在细胞质或其他细胞隔室中的代谢过程之间的联系方面取得了重大进展。初级代谢产物和细胞氧化还原状态影响染色质修饰复合物，而染色质修饰物反过来又影响代谢基因的表达。目前的证据表明，这些生物系统层之间存在复杂的相互作用环。应用跨学科和整体的方法将阐明染色质结构、代谢和植物生长发育之间动态串扰的因果关系和分子机制。
