Bhuiyan Md Saruar, Jiang Jhih-Hang, Kostoulias Xenia, Theegala Ravali, Lieschke Graham J, Peleg Anton Y
Infection and Immunity Program, Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, VIC 3800, Australia.
Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia.
Antibiotics (Basel). 2021 Jan 20;10(2):96. doi: 10.3390/antibiotics10020096.
Daptomycin is an important antibiotic for the treatment of infections caused by . The emergence of daptomycin resistance in is associated with treatment failure and persistent infections with poor clinical outcomes. Here, we investigated host innate immune responses against clinically derived, daptomycin-resistant (DAP-R) and -susceptible paired isolates using a zebrafish infection model. We showed that the control of DAP-R infections was attenuated in vivo due to cross-resistance to host cationic antimicrobial peptides. These data provide mechanistic understanding into persistent infections caused by DAP-R and provide crucial insights into the adaptive evolution of this troublesome pathogen.
达托霉素是治疗由……引起的感染的一种重要抗生素。……中达托霉素耐药性的出现与治疗失败及临床预后不良的持续性感染有关。在此，我们使用斑马鱼感染模型研究了宿主针对临床分离的、对达托霉素耐药（DAP-R）和敏感的……配对菌株的固有免疫反应。我们发现，由于对宿主阳离子抗菌肽的交叉耐药性，DAP-R……感染在体内的控制减弱。这些数据为DAP-R……引起的持续性感染提供了机制上的理解，并为这种麻烦病原体的适应性进化提供了关键见解。
