• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
p38 Signalling Pathway.p38 信号通路。
Int J Mol Sci. 2021 Jan 20;22(3):1003. doi: 10.3390/ijms22031003.
2
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways.基于没食子酰苯甲酰胺的化合物调节肿瘤坏死因子α刺激的c-Jun N端激酶和p38丝裂原活化蛋白激酶信号通路。
J Pharm Pharmacol. 2015 Oct;67(10):1380-92. doi: 10.1111/jphp.12438. Epub 2015 Jun 16.
3
Stress-activated kinase pathway alteration is a frequent event in bladder cancer.应激激活激酶通路改变是膀胱癌的常见事件。
Urol Oncol. 2012 Jul-Aug;30(4):415-20. doi: 10.1016/j.urolonc.2010.03.002. Epub 2011 Dec 11.
4
Vitamin A deficiency suppresses fish immune function with differences in different intestinal segments: the role of transcriptional factor NF-κB and p38 mitogen-activated protein kinase signalling pathways.维生素A缺乏会抑制鱼类免疫功能，不同肠道段存在差异：转录因子NF-κB和p38丝裂原活化蛋白激酶信号通路的作用
Br J Nutr. 2017 Jan;117(1):67-82. doi: 10.1017/S0007114516003342. Epub 2017 Jan 18.
5
[MAPK signaling pathway and erectile dysfunction].[丝裂原活化蛋白激酶信号通路与勃起功能障碍]
Zhonghua Nan Ke Xue. 2018 May;24(5):442-446.
6
p38 mitogen activated protein kinase mediates cardiac Na/H exchanger inhibition induced by Sildenafil.p38 丝裂原活化蛋白激酶介导西地那非抑制心脏钠氢交换器。
Eur J Pharmacol. 2019 Apr 15;849:96-105. doi: 10.1016/j.ejphar.2019.01.070. Epub 2019 Feb 2.
7
[Glabridin reduces lipopolysaccharide-induced lung injury in rats by inhibiting p38 mitogen activated protein kinase/extracellular regulated protein kinases signaling pathway].光甘草定通过抑制p38丝裂原活化蛋白激酶/细胞外调节蛋白激酶信号通路减轻大鼠脂多糖诱导的肺损伤
Zhonghua Yi Xue Za Zhi. 2016 Dec 27;96(48):3893-3897. doi: 10.3760/cma.j.issn.0376-2491.2016.48.009.
8
Comparative analysis of regulatory roles of P38 signaling pathway in 8 types liver cell during liver regeneration.P38信号通路在肝脏再生过程中对8种肝细胞调节作用的比较分析
Gene. 2016 Dec 5;594(1):66-73. doi: 10.1016/j.gene.2016.08.056. Epub 2016 Sep 1.
9
Activation and signaling of the p38 MAP kinase pathway.p38丝裂原活化蛋白激酶信号通路的激活与信号传导。
Cell Res. 2005 Jan;15(1):11-8. doi: 10.1038/sj.cr.7290257.
10
The activation of ERK1/2 and p38 mitogen-activated protein kinases is dynamically regulated in the developing rat visual system.在发育中的大鼠视觉系统中，ERK1/2和p38丝裂原活化蛋白激酶的激活受到动态调节。
Int J Dev Neurosci. 2008 May-Jun;26(3-4):355-62. doi: 10.1016/j.ijdevneu.2007.12.007. Epub 2008 Jan 6.

引用本文的文献

1
Pyrimethamine Inhibits Human Ovarian Cancer by Triggering Lethal Mitophagy via Activating the p38/JNK/ERK Pathway.乙胺嘧啶通过激活p38/JNK/ERK途径触发致死性线粒体自噬来抑制人卵巢癌。
Oncol Res. 2025 Aug 28;33(9):2421-2434. doi: 10.32604/or.2025.063724. eCollection 2025.
2
Ginsenoside Rh2 alleviates inflammatory response and enhances motor function recovery in spinal cord injury mice via the ROS/MAPK14 signaling pathway.人参皂苷Rh2通过ROS/MAPK14信号通路减轻脊髓损伤小鼠的炎症反应并促进运动功能恢复。
J Ginseng Res. 2025 Jul;49(4):415-425. doi: 10.1016/j.jgr.2025.03.008. Epub 2025 Mar 28.
3
The relationship mammalian p38 with human health and its homolog Hog1 in response to environmental stresses in .哺乳动物p38与其同源物Hog1在应对环境压力时与人类健康的关系。 （注：原英文文本表述不太完整规范，翻译后的中文也稍显拗口，但尽量忠实于原文进行了翻译）
Front Cell Dev Biol. 2025 Mar 10;13:1522294. doi: 10.3389/fcell.2025.1522294. eCollection 2025.
4
Natural products modulating MAPK for CRC treatment: a promising strategy.天然产物调节丝裂原活化蛋白激酶用于结直肠癌治疗：一种有前景的策略。
Front Pharmacol. 2025 Mar 5;16:1514486. doi: 10.3389/fphar.2025.1514486. eCollection 2025.
5
Raddeanin A promotes the apoptosis of gastric cancer in conjunction with autophagy inhibitor Hydroxychloroquine via MAPK signaling pathway.鸦胆子甲素A通过丝裂原活化蛋白激酶（MAPK）信号通路，与自噬抑制剂羟氯喹协同促进胃癌细胞凋亡。
J Tradit Complement Med. 2024 Jul 20;15(2):161-169. doi: 10.1016/j.jtcme.2024.07.004. eCollection 2025 Mar.
6
Chinese medicine in the treatment of chronic hepatitis B: The mechanisms of signal pathway regulation.中医治疗慢性乙型肝炎：信号通路调控机制
Heliyon. 2024 Oct 12;10(20):e39176. doi: 10.1016/j.heliyon.2024.e39176. eCollection 2024 Oct 30.
7
The Protective Role of Interleukin-37 in Cardiovascular Diseases through Ferroptosis Modulation.白细胞介素-37 通过调控铁死亡在心血管疾病中发挥保护作用。
Int J Mol Sci. 2024 Sep 10;25(18):9758. doi: 10.3390/ijms25189758.
8
Oleanolic acid improves 5-fluorouracil-induced intestinal damage and inflammation by alleviating intestinal senescence.齐墩果酸通过减轻肠道衰老改善 5-氟尿嘧啶诱导的肠道损伤和炎症。
Sci Rep. 2024 Sep 19;14(1):21852. doi: 10.1038/s41598-024-72536-3.
9
P38α MAPK Coordinates Mitochondrial Adaptation to Caloric Surplus in Skeletal Muscle.P38α MAPK 协调骨骼肌对热量过剩的线粒体适应。
Int J Mol Sci. 2024 Jul 16;25(14):7789. doi: 10.3390/ijms25147789.
10
Rosuvastatin attenuates airway inflammation and remodeling in a chronic allergic asthma model through modulation of the AMPKα signaling pathway.瑞舒伐他汀通过调节 AMPKα 信号通路减轻慢性变应性哮喘模型中的气道炎症和重塑。
PLoS One. 2024 Jun 24;19(6):e0305863. doi: 10.1371/journal.pone.0305863. eCollection 2024.

本文引用的文献

1
p38β and Cancer: The Beginning of the Road.p38β 与癌症：征途伊始。
Int J Mol Sci. 2020 Oct 12;21(20):7524. doi: 10.3390/ijms21207524.
2
p38 MAPK Pathway in the Heart: New Insights in Health and Disease.心脏中的p38丝裂原活化蛋白激酶信号通路：健康与疾病的新见解
Int J Mol Sci. 2020 Oct 8;21(19):7412. doi: 10.3390/ijms21197412.
3
Transcriptomic Evaluation of Pulmonary Fibrosis-Related Genes: Utilization of Transgenic Mice with Modifying p38 Signal in the Lungs.肺纤维化相关基因的转录组评估：利用肺部 p38 信号修饰的转基因小鼠。
Int J Mol Sci. 2020 Sep 14;21(18):6746. doi: 10.3390/ijms21186746.
4
p38 MAPK in Glucose Metabolism of Skeletal Muscle: Beneficial or Harmful?p38 MAPK 在骨骼肌葡萄糖代谢中的作用：有益还是有害？
Int J Mol Sci. 2020 Sep 4;21(18):6480. doi: 10.3390/ijms21186480.
5
Nuclear P38: Roles in Physiological and Pathological Processes and Regulation of Nuclear Translocation.核 P38：在生理和病理过程中的作用及核易位的调节。
Int J Mol Sci. 2020 Aug 24;21(17):6102. doi: 10.3390/ijms21176102.
6
P38 Regulates Kainic Acid-Induced Seizure and Neuronal Firing via Kv4.2 Phosphorylation.P38 通过调节 Kv4.2 磷酸化来调控海人酸诱导的癫痫发作和神经元放电。
Int J Mol Sci. 2020 Aug 18;21(16):5921. doi: 10.3390/ijms21165921.
7
Involvement of p38 MAPK in Synaptic Function and Dysfunction.p38MAPK 在突触功能和功能障碍中的作用。
Int J Mol Sci. 2020 Aug 6;21(16):5624. doi: 10.3390/ijms21165624.
8
P38α MAPK Signaling-A Robust Therapeutic Target for Rab5-Mediated Neurodegenerative Disease.P38α MAPK 信号通路——Rab5 介导的神经退行性疾病的一个稳健治疗靶点。
Int J Mol Sci. 2020 Jul 31;21(15):5485. doi: 10.3390/ijms21155485.
9
Is p38 MAPK Associated to Drugs of Abuse-Induced Abnormal Behaviors?p38 MAPK 是否与药物滥用引起的异常行为有关？
Int J Mol Sci. 2020 Jul 8;21(14):4833. doi: 10.3390/ijms21144833.
10
The MKK-Dependent Phosphorylation of p38α Is Augmented by Arginine Methylation on Arg49/Arg149 during Erythroid Differentiation.在红细胞分化过程中，精氨酸甲基化对 Arg49/Arg149 的修饰增强了 MKK 依赖性的 p38α 的磷酸化。
Int J Mol Sci. 2020 May 17;21(10):3546. doi: 10.3390/ijms21103546.

p38 信号通路。

p38 Signalling Pathway.

机构信息

Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología/CSIC (CNB-CSIC), Campus-UAM, 28049 Madrid, Spain.

Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC (CNB-CSIC), Campus-UAM, 28049 Madrid, Spain.

出版信息

Int J Mol Sci. 2021 Jan 20;22(3):1003. doi: 10.3390/ijms22031003.

DOI:10.3390/ijms22031003
PMID:33498296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7863928/
Abstract

p38 Mitogen activated protein kinases (p38MAPK) are a highly evolutionary conserved group of protein kinases, which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration, and tumour formation [...].

摘要

p38 丝裂原活化蛋白激酶（p38MAPK）是一组高度进化保守的蛋白激酶，对于细胞适应环境变化以及免疫反应、炎症、组织再生和肿瘤形成等过程至关重要[... ]。