Williams D J, York E L, Nobert E J, Sproule B J
Department of Pulmonary Medicine, W. Mackenzie Center, University of Alberta, Edmonton, Canada.
Chest. 1988 Apr;93(4):836-8. doi: 10.1378/chest.93.4.836.
Clinical deterioration with features suggestive of asthma was seen in three patients following two to six months of drug therapy of primary tuberculosis. There was a poor clinical response to administered bronchodilators. Bronchoscopy in all three revealed culture-negative mycobacterial caseating granulomas. Corticosteroid therapy resulted in good clinical response, with resolution of the asthmatic symptoms and improvement in the expiratory flow rates. In our opinion these patients are clinically compatible with a hypersensitivity response to mycobacteria following antituberculosis therapy and release of tuberculosis antigens. Corticosteroid therapy is appropriate in this form of tuberculous disease.
