Medical Academy Named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Lenin Boulevard 5/7, 295051 Simferopol, Russia.
Taurida Academy, V.I. Vernadsky Crimean Federal University, Vernadsky Av. 4, 295007 Simferopol, Russia.
Int J Mol Sci. 2021 Jan 20;22(3):1022. doi: 10.3390/ijms22031022.
The urgency of the search for inexpensive and effective drugs with localized action for the treatment of rheumatoid arthritis continues unabated. In this study, for the first time we investigated the Cytos-11 antisense oligonucleotide suppression of TNF-α gene expression in a rat model of rheumatoid arthritis induced by complete Freund's adjuvant. Cytos-11 has been shown to effectively reduce peripheral blood concentrations of TNF-α, reduce joint inflammation, and reduce pannus development. The results achieved following treatment with the antisense oligonucleotide Cytos-11 were similar to those of adalimumab (Humira); they also compared favorably with those results, which provides evidence of the promise of drugs based on antisense technologies in the treatment of this disease.
寻找具有局部作用且价格低廉、疗效显著的药物来治疗类风湿性关节炎的需求依然十分迫切。在本研究中，我们首次研究了 Cytos-11 反义寡核苷酸对完全弗氏佐剂诱导的类风湿性关节炎大鼠模型中 TNF-α 基因表达的抑制作用。研究表明 Cytos-11 可有效降低外周血 TNF-α 浓度，减轻关节炎症，减少血管翳形成。Cytos-11 反义寡核苷酸治疗后的结果与阿达木单抗（Humira）相似，与这些结果相比也具有优势，这为基于反义技术的药物治疗这种疾病提供了前景。
