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复制偶联染色质重塑：复制过程中染色质解聚与组装概述。

Replication-Coupled Chromatin Remodeling: An Overview of Disassembly and Assembly of Chromatin during Replication.

机构信息

UFIP UMR-CNRS 6286, Épigénétique et Dynamique de la Chromatine, Université de Nantes, 2 rue de la Houssinière, 44322 Nantes, France.

出版信息

Int J Mol Sci. 2021 Jan 23;22(3):1113. doi: 10.3390/ijms22031113.

DOI:10.3390/ijms22031113
PMID:33498649
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7865951/
Abstract

The doubling of genomic DNA during the S-phase of the cell cycle involves the global remodeling of chromatin at replication forks. The present review focuses on the eviction of nucleosomes in front of the replication forks to facilitate the passage of replication machinery and the mechanism of replication-coupled chromatin assembly behind the replication forks. The recycling of parental histones as well as the nuclear import and the assembly of newly synthesized histones are also discussed with regard to the epigenetic inheritance.

摘要

在细胞周期的 S 期，基因组 DNA 会加倍，这涉及到复制叉处染色质的全局重塑。本综述重点介绍了复制叉前核小体的排出，以促进复制机制的通过，以及复制叉后染色质组装的机制。还讨论了亲本组蛋白的回收以及新合成组蛋白的核输入和组装，以及与表观遗传遗传有关的问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e0/7865951/16c00fccf3c8/ijms-22-01113-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e0/7865951/2d35508d7367/ijms-22-01113-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e0/7865951/aa7f75e5b9fa/ijms-22-01113-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e0/7865951/16c00fccf3c8/ijms-22-01113-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e0/7865951/2d35508d7367/ijms-22-01113-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e0/7865951/aa7f75e5b9fa/ijms-22-01113-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4e0/7865951/16c00fccf3c8/ijms-22-01113-g003.jpg

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本文引用的文献

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H1 histones control the epigenetic landscape by local chromatin compaction.H1 组蛋白通过局部染色质紧缩控制表观遗传景观。
Nature. 2021 Jan;589(7841):293-298. doi: 10.1038/s41586-020-3032-z. Epub 2020 Dec 9.
3
Histone Variants: Guardians of Genome Integrity.组蛋白变体：基因组完整性的守护者。
重塑因子和组蛋白片段介导的随机核小体解体。
J Chem Phys. 2023 Nov 28;159(20). doi: 10.1063/5.0165136.
4
Effects of replication domains on genome-wide UV-induced DNA damage and repair.复制域对全基因组 UV 诱导的 DNA 损伤和修复的影响。
PLoS Genet. 2022 Sep 26;18(9):e1010426. doi: 10.1371/journal.pgen.1010426. eCollection 2022 Sep.
Cells. 2020 Nov 5;9(11):2424. doi: 10.3390/cells9112424.
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Single-molecule imaging reveals control of parental histone recycling by free histones during DNA replication.单分子成像揭示了在 DNA 复制过程中游离组蛋白对亲本组蛋白回收的控制。
Sci Adv. 2020 Sep 18;6(38). doi: 10.1126/sciadv.abc0330. Print 2020 Sep.
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The replisome guides nucleosome assembly during DNA replication.复制体在DNA复制过程中指导核小体组装。
Cell Biosci. 2020 Mar 12;10:37. doi: 10.1186/s13578-020-00398-z. eCollection 2020.
6
Active and Repressed Chromatin Domains Exhibit Distinct Nucleosome Segregation during DNA Replication.活跃和被抑制的染色质结构域在 DNA 复制过程中表现出不同的核小体分离。
Cell. 2019 Oct 31;179(4):953-963.e11. doi: 10.1016/j.cell.2019.10.009.
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