Pontisso Ilaria, Combettes Laurent
UMR 1282, INSERM, Laboratoire de Biologie et Pharmacologie Appliquée, Ecole Normale Supérieure Paris Saclay, 91190 Gif Sur Yvette, France.
Faculté des Sciences, Université Paris-Saclay, 91405 Orsay, France.
Genes (Basel). 2021 Jan 22;12(2):139. doi: 10.3390/genes12020139.
Ca signaling plays a pivotal role in the control of cellular homeostasis and aberrant regulation of Ca fluxes have a strong impact on cellular functioning. As a consequence of this ubiquitous role, Ca signaling dysregulation is involved in the pathophysiology of multiple diseases including cancer. Indeed, multiple studies have highlighted the role of Ca fluxes in all the steps of cancer progression. In particular, the transfer of Ca at the ER-mitochondrial contact sites, also known as mitochondrial associated membranes (MAMs), has been shown to be crucial for cancer cell survival. One of the proteins enriched at this site is the sigma-1 receptor (S1R), a protein that has been described as a Ca-sensitive chaperone that exerts a protective function in cells in various ways, including the modulation of Ca signaling. Interestingly, S1R is overexpressed in many types of cancer even though the exact mechanisms by which it promotes cell survival are not fully elucidated. This review summarizes the findings describing the roles of S1R in the control of Ca signaling and its involvement in cancer progression.
钙信号传导在细胞稳态控制中起关键作用，钙通量的异常调节对细胞功能有强烈影响。由于其普遍存在的作用，钙信号失调与包括癌症在内的多种疾病的病理生理学有关。事实上，多项研究强调了钙通量在癌症进展的所有步骤中的作用。特别是，在内质网 - 线粒体接触位点（也称为线粒体相关膜，即MAMs）处的钙转运已被证明对癌细胞存活至关重要。在该位点富集的一种蛋白质是sigma-1受体（S1R），一种被描述为钙敏感伴侣蛋白的蛋白质，它通过多种方式在细胞中发挥保护作用，包括调节钙信号传导。有趣的是，S1R在许多类型的癌症中过表达，尽管其促进细胞存活的确切机制尚未完全阐明。本综述总结了描述S1R在控制钙信号传导中的作用及其参与癌症进展的研究结果。
