Joseph Ashley M, Shames Stephanie R
Division of Biology, Kansas State University, Manhattan, KS 66506, USA.
Pathogens. 2021 Jan 22;10(2):108. doi: 10.3390/pathogens10020108.
Many bacterial pathogens utilize translocated virulence factors called effectors to successfully infect their host. Within the host cell, effector proteins facilitate pathogen replication through subversion of host cell targets and processes. is a Gram-negative intracellular bacterial pathogen that relies on hundreds of translocated effectors to replicate within host phagocytes. Within this large arsenal of translocated effectors is a unique subset of effectors called metaeffectors, which target and regulate other effectors. At least one dozen metaeffectors are encoded by ; however, mechanisms by which they promote virulence are largely unknown. This review details current knowledge of metaeffector function, challenges associated with their identification, and potential avenues to reveal the contribution of metaeffectors to bacterial pathogenesis.
许多细菌病原体利用称为效应蛋白的易位毒力因子来成功感染宿主。在宿主细胞内，效应蛋白通过破坏宿主细胞靶点和过程来促进病原体复制。是一种革兰氏阴性细胞内细菌病原体，它依靠数百种易位效应蛋白在宿主吞噬细胞内复制。在这个庞大的易位效应蛋白库中，有一个独特的效应蛋白子集称为元效应蛋白，它们靶向并调节其他效应蛋白。至少有一打元效应蛋白由编码；然而，它们促进毒力的机制在很大程度上尚不清楚。这篇综述详细介绍了目前关于元效应蛋白功能的知识、与它们识别相关的挑战，以及揭示元效应蛋白对细菌致病作用贡献的潜在途径。
