Sievert H, Offermann T, Bussmann W D, Hopf R, Kaltenbach M
Abteilung für Kardiologie, Universitätsklinikum Frankfurt/Main.
Dtsch Med Wochenschr. 1988 Mar 25;113(12):463-6. doi: 10.1055/s-2008-1067663.
Eight patients in sinus rhythm with chronic heart failure were studied. After individually adjusted six-week treatment with diuretics (hydrochlorothiazide-triamtere and/or frusemide) all patients were clearly improved symptomatically. Subsequently they additionally received digitoxin for six weeks, 0.07-0.1 mg daily. Before and at the end of the digitoxin period cardiac volume was determined radiologically, echocardiography was performed and haemodynamic parameters determined at rest and on exercise via indwelling catheters. During digitoxin administration there was a slight increase in cardiac output from 4.63 +/- 0.82 to 5.05 +/- 0.98 l/min (P less than 0.1) at rest and from 7.22 +/- 1.94 to 7.79 +/- 2.59 l/min at rest. The mean values of all other haemodynamic parameters remained unchanged. These results suggest that in patients with chronic heart failure and sinus rhythm any clinical or haemodynamic improvement achieved will not be significantly bettered by digitoxin.
对8例慢性心力衰竭且处于窦性心律的患者进行了研究。在用利尿剂（氢氯噻嗪-氨苯蝶啶和/或呋塞米）进行为期6周的个体化调整治疗后，所有患者的症状均明显改善。随后，他们额外接受了为期6周的洋地黄毒苷治疗，每日剂量为0.07 - 0.1毫克。在洋地黄毒苷治疗期开始前及结束时，通过放射学方法测定心脏容积，进行超声心动图检查，并通过留置导管测定静息和运动时的血流动力学参数。在给予洋地黄毒苷期间，静息时心输出量略有增加，从4.63±0.82升/分钟增至5.05±0.98升/分钟（P＜0.1），运动时从7.22±1.94升/分钟增至7.79±2.59升/分钟。所有其他血流动力学参数的平均值保持不变。这些结果表明，对于慢性心力衰竭且处于窦性心律的患者，洋地黄毒苷不会使已取得的任何临床或血流动力学改善显著增强。
