Center for Surgical Outcomes Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, 611 East Livingston Avenue, Columbus, OH, 43205, United States.
Center for Surgical Outcomes Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, 611 East Livingston Avenue, Columbus, OH, 43205, United States; Department of Pediatric Surgery, Nationwide Children's Hospital, 611 East Livingston Avenue, Columbus, OH 43205, United States.
J Pediatr Surg. 2021 Nov;56(11):2099-2106. doi: 10.1016/j.jpedsurg.2021.01.009. Epub 2021 Jan 14.
Adults with sarcopenia have a greater risk of postoperative complications, a higher rate of ICU admission, and an increased length of hospital stay. Few studies have explored the prevalence or importance of sarcopenia in the pediatric population. This study reviews the published literature on sarcopenia in the pediatric population, including pediatric surgery.
Original studies related to sarcopenia in children were identified using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines and the PubMed database.
A total of 390 articles were screened, with 28 meeting inclusion criteria. Twenty (71%) studies provided a means to define abnormal and 18 studies (64%) showed that a specific disease process could impact lean muscle mass in children. Only 4 (14%) studies associated the change in muscle mass with an outcome. Two studies investigated sarcopenia and outcomes in the pediatric surgical patient and demonstrated associations with worse outcomes.
Despite studies showing an association between sarcopenia and negative outcomes in the adult surgical population, there remains a paucity of evidence regarding the impact of sarcopenia on the pediatric population. Future studies are needed to ascertain the relationship between muscle mass and outcomes in pediatric surgical patients.
患有肌少症的成年人术后并发症风险更高，入住 ICU 的比例更高，住院时间更长。很少有研究探讨肌少症在儿科人群中的患病率或重要性。本研究回顾了发表的关于儿科人群肌少症的文献，包括儿科手术。
使用系统评价和荟萃分析扩展的首选报告项目（PRISMA-ScR）指南和 PubMed 数据库确定与儿童肌少症相关的原始研究。
共筛选出 390 篇文章，其中 28 篇符合纳入标准。20 项（71%）研究提供了定义异常的方法，18 项研究（64%）表明特定的疾病过程可能会影响儿童的瘦肌肉量。只有 4 项（14%）研究将肌肉量的变化与结果相关联。两项研究调查了肌少症和儿科手术患者的结果，并表明与较差的结果相关。
尽管研究表明肌少症与成人外科患者的不良结果之间存在关联，但关于肌少症对儿科人群影响的证据仍然不足。需要进一步的研究来确定儿科手术患者肌肉量与结果之间的关系。
