Cain D P, Corcoran M E, Desborough K A, McKitrick D J
Department of Psychology, University of Western Ontario, London, Canada.
Exp Neurol. 1988 Apr;100(1):203-9. doi: 10.1016/0014-4886(88)90212-9.
Rats were electrically kindled in deep prepyriform cortex (DPC) and in immediately surrounding areas, pyriform cortex, and the basolateral amygdala in an effort to identify an area of the basal forebrain crucially involved in epileptogenesis and the kindling of seizures. Picomolar quantities of carbachol were also microinjected into DPC. All of these areas kindled at equivalent rates. Injection of picomolar quantities of carbachol failed to evoke epileptiform spiking, but injection of nanomolar quantities of carbachol usually evoked epileptiform spiking. Bilateral radiofrequency lesions of the DPC did not affect the rate of electrical kindling of the basolateral amygdala. We conclude that the DPC kindles readily at a rate that is similar to that of surrounding basal forebrain tissue and that the integrity of the DPC is not necessary for basolateral amygdaloid kindling.
为了确定基底前脑中一个在癫痫发生和癫痫发作点燃过程中至关重要的区域，对大鼠的深部梨状前皮质（DPC）及其紧邻区域、梨状皮质和基底外侧杏仁核进行电点燃。还将皮摩尔量的卡巴胆碱微量注射到DPC中。所有这些区域以相同的速率点燃。注射皮摩尔量的卡巴胆碱未能诱发癫痫样棘波，但注射纳摩尔量的卡巴胆碱通常会诱发癫痫样棘波。DPC的双侧射频损伤并不影响基底外侧杏仁核的电点燃速率。我们得出结论，DPC很容易以与周围基底前脑组织相似的速率点燃，并且DPC的完整性对于基底外侧杏仁核的点燃并非必需。
