破伤风毒素和肉毒杆菌A毒素对大鼠脑匀浆中[3H]去甲肾上腺素和[3H]γ-氨基丁酸释放的抑制作用。
Inhibition by tetanus and botulinum A toxin of the release of [3H]noradrenaline and [3H]GABA from rat brain homogenate.
作者信息
Habermann E
机构信息
Buchheim-Institut für Pharmakologie der Justus-Liebig-Universität, Giessen, Federal Republic of Germany.
出版信息
Experientia. 1988 Mar 15;44(3):224-6. doi: 10.1007/BF01941714.
PMID:3350134
Abstract
Rat brain homogenate was preloaded with [3H]noradrenaline or [3H]GABA and stimulated with high K+. Tetanus toxin and botulinum A neurotoxin partially prevent the evoked [3H]noradrenaline release in the same range of toxin concentrations starting below 10(-10) M. In contrast, release of gamma-amino butyric acid (GABA) is much more sensitive to tetanus than to botulinum A toxin.
摘要
将大鼠脑匀浆用[3H]去甲肾上腺素或[3H]γ-氨基丁酸（GABA）预负载，并用高钾刺激。破伤风毒素和肉毒杆菌A神经毒素在低于10（-10）M的相同毒素浓度范围内，部分地抑制诱发的[3H]去甲肾上腺素释放。相比之下，γ-氨基丁酸（GABA）的释放对破伤风毒素比对肉毒杆菌A毒素更为敏感。
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