Department of Neurology, DKD Helios Klinik Wiesbaden, Aukammallee 33, 65191, Wiesbaden, Germany.
Headache Science Centre, IRCCS Mondino Foundation, 27100, Pavia, Italy.
Neurotherapeutics. 2018 Apr;15(2):313-323. doi: 10.1007/s13311-018-0621-8.
A relatively high number of different medications is currently used for migraine prevention in clinical practice. Although these compounds were initially developed for other indications and differ in their mechanisms of action, some general themes can be identified from the mechanisms at play. Efficacious preventive drugs seem to either suppress excitatory nervous signaling via sodium and/or calcium receptors, facilitate GABAergic inhibition, reduce neuronal sensitization, block cortical spreading depression and/or reduce circulating levels of CGRP. We here review such mechanisms for the different compounds.
目前在临床实践中，有相当多种类的药物被用于偏头痛的预防。尽管这些化合物最初是为其他适应症开发的，且作用机制不同，但从作用机制中可以确定一些共同的主题。有效的预防药物似乎要么通过钠和/或钙受体抑制兴奋性神经信号传导，要么促进 GABA 能抑制，减少神经元敏化，阻断皮质扩散性抑制，或降低 CGRP 的循环水平。在此，我们综述了这些不同化合物的此类机制。
